Results 71 to 80 of about 957,516 (310)
Engineering Ethics and Self-Organizing Models of Human Development: Opportunities and Challenges [PDF]
, 2017 Insoo Hyun
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Condições de trabalho e automação: o caso do soprador da indústria vidreira
Revista de Saúde PúblicaOBJETIVO: Investigar como o controle de tarefas e o uso de diferentes tecnologias e de estrutura organizacional determinam o processo de saúde-doença. MÉTODOS: O estudo foi desenvolvido em duas indústrias vidreiras -- automática e manual --, no Município
Maria de Fátima F Queiróz +1 more
doaj
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Ideal-Type Narratives for Engineering a Human Niche
Geosciences, 2017 Humans have built an anthropocentric biogeosphere; called: ‘human niche’. Global change is part of this historical process of niche construction, which implies the intersection of the biogeosphere and the sphere of human activities of social, economic ...
Martin Bohle
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Gonal-f RFF® Redi-ject™: Optimization of Use with Simulated Use Testing and Human Factors Engineering [PDF]
, 2014 M.C. Mahony +5 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering the human blood-brain barrier in vitro
Journal of Biological Engineering, 2017 The blood-brain barrier (BBB) is the interface between the vasculature and the brain, regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form the capillary walls constitute the physical barrier but are dependent on ...
John J. Jamieson +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source