Results 91 to 100 of about 4,206,748 (294)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Precision trimmer aids in preparing biomedical specimen blocks for ultrathin sectioning [PDF]
, 1967 Precision trimmer, which neatly trims biomedical specimen blocks for ultrathin sectioning, eliminates the risk of human error. Four inches in diameter and 3 inches in height, it supports the block and serves as a support for a cutting tool and can be ...
Tahmisian, T. N.
core +1 more source
Salāmat-i kār-i Īrān, 2017 Background and aims: With a widespread regard to the human error issue and recognize the importance of human as an active processor of information The necessity for an effective framework to analyze different mental processes interact with the system to
Gholam.Abbas Shirali +11 more
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Explaining the Negative Coefficient Associated with Human Capital in Augmented Solow Growth Regressions [PDF]
In this paper we consider different explanations for why the coefficient associated with human capital is often negative in growth regressions once country-specific effects are controlled for whereas the coefficient in question is strongly positive in ...
Béatrice D'HOMBRES, Jean-Louis ARCAND
core
Technology Vs Nature: Human Error in Dealing with Nature in Crichton\u27s Jurassic Park [PDF]
, 2000 Witnessing the euphoria of the era of biotechnology in the late twentieth century, Crichton exposes the theme of biotechnology in his works. In Jurassic Park, he voices his concern about the impact of the use of biotechnology to preserve nature and its ...
Prasasti, S. (Sarah) +1 more
core +1 more source
Salāmat-i kār-i Īrān, 2014 Background and aims: Permit to work (P.T.W) is a formal written system to control certain types of work which are identified as potentially hazardous.
N Hobobi, M Jahangiri, S Keshavarzi
doaj
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source