E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Assessment of the incidence and nature of adverse events and their association with human error in neurosurgery. A prospective observation. [PDF]
Brain Spine, 2022 Meyer HS +7 more
europepmc +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Micro-Behavioral Accidental Click Detection System for Preventing Slip-Based Human Error. [PDF]
Sensors (Basel), 2021 Almehmadi A.
europepmc +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Consequences of Data Error in Aggregate Indicators: Evidence from the Human Development Index [PDF]
This paper examines the consequences of data error in data series used to construct aggregate indicators. Using the most popular indicator of country level economic development, the Human Development Index (HDI), we identify three separate sources of ...
Auffhammer, Maximilian +2 more
core
Human Error Probability Determination in Blasting Process of Ore Mine Using a Hybrid of HEART and Best-Worst Methods. [PDF]
Saf Health Work, 2022 Mirzaei Aliabadi M +3 more
europepmc +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Medical errors: Mandatory reporting, voluntary reporting, or both? [PDF]
This work evaluates policy recommendations on medical error reporting systems presented in, To err is human, a report published by the Institute of Medicine.
Grepperud, Sverre
core
Assessment and analysis of studies related human error in Iran: A systematic review
بهداشت و ایمنی کار, 2017 Introduction: Despite the ongoing efforts to reduce human errors in various systems, errors and unsafe behavior are the main cause of accidents in the workplace. Many studies have been conducted to identify and improve human error in recent years.
Asma Zare +4 more
doaj