Results 61 to 70 of about 4,206,748 (294)
Safety and Health at Work, 2014 Investigation and analysis of accidents are critical elements of safety management. The over-riding purpose of an organization in carrying out an accident investigation is to prevent similar accidents, as well as seek a general improvement in the ...
Aikaterini D. Baka, Nikolaos K. Uzunoglu
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A simple yet effective baseline for 3d human pose estimation
, 2017 Following the success of deep convolutional networks, state-of-the-art methods for 3d human pose estimation have focused on deep end-to-end systems that predict 3d joint locations given raw image pixels.
Hossain, Rayat +3 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Learning curve assessment of rule use provides evidence for spared implicit sequence learning in a mouse model of mental retardation [PDF]
, 2009 Humans with Fragile X Syndrome (FXS) have a mental retardation of which a notable characteristic is a weakness in recalling sequences of information. A mouse model of the disorder exists which exhibits behavioral and neurologic changes, but cognitive ...
Bauchwitz, Dr. Robert
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Analisis Penyebab Pipa Cacat dengan Metode Fault Tree Analysis (Studi Kasus pada PT. Indonesia Steel Tube Works – Semarang) [PDF]
, 2013 Abstrak PT. Indonesia Steel Tube Works (ISTW) adalah perusahaan joint venture antara Indonesia dan Jepang yang memproduksi pipa baja. Dari studi pendahuluan terdapat beberapa jenis cacat untuk periode Oktober-Desember 2011.
HAMONANGAN S, RICHARD +1 more
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Measurement Error in Research on Human Resources and Firm Performance: Additional Data and Suggestions for Future Research [PDF]
, 2000 Gerhart and colleagues and Huselid and Becker recently debated the presence and implications of measurement error in measures of human resource practices.
Delery, John +5 more
core +1 more source