Results 71 to 80 of about 4,206,748 (294)
Agriculture, 2019 The use of pesticides in agriculture is a significant problem at a global level, not only from an environmental perspective but also from the farmers’ health and safety point of view.
Mario Fargnoli +2 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Human Error and Organizational Management [PDF]
The concern for performance is a topic that raises interest in the business environment but also in other areas that – even if they seem distant from this world – are aware of, interested in or conditioned by the economy development.
Alecxandrina DEACONU, Lavinia RASCA
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A survey of spatial disorientation incidence in Polish military pilots
International Journal of Occupational Medicine and Environmental Health, 2020 Objectives The study aimed to establish the current incidence and severity of spatial disorientation (SD) in Polish military pilots when flying different aircraft types over their entire careers, and to determine how SD training and pilots’ flight ...
Rafał Lewkowicz, Marcin Piotr Biernacki
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Routes to failure and prevention recommendations in work systems of hydropower construction
Journal of Civil Engineering and Management, 2018 There are many types of accidents with their own characteristics in hydropower construction. The accidents are mainly results of human errors. It is important to find out the routes to failure and give recommendations pertinently for different accident ...
Xiazhong Zheng +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
بهداشت و ایمنی کار, 2019 Introduction: Nowadays, accidents are regarded as a main risk factor for both human and economic of countries. The triggerring cause of most accident is human error.
Samaneh Salari +3 more
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