Results 101 to 110 of about 2,157,299 (268)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The highlighting divide: does highlighting strategy help explain international gaps in reading achievement?

Large-scale Assessments in Education
Background While highlighting is one of the most common strategies to enhance reading comprehension, little is known about how highlighting behavior and its relationship with performance varies across cultures.
Ella Anghel, Matthias von Davier
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Evaluating Human Capital Obsolescence

, 2006
Human resources are playing a central role in the knowledge economy that emerged in the Western world as the human capital embodied in both high-tech capital goods and the working population is a main determinant of the performance of individuals, organizations and national economies.
openaire   +3 more sources

Measurement and Evaluation of Human Functions

, 2018
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Kurdak, Sadi, Yazıhan, Nuray, Ermutlu, Numan, Kutlu, Selim, Ayar, Ahmet, Kozanoğlu, İlknur   +5 more
openaire   +2 more sources

A Comparison of Leg Muscle Oxygenation, Cardiorespiratory Responses, and Blood Lactate between Walking and Running at the Same Speed

Sports
It is not known whether different gait modes, or movement patterns, at the same speed elicit differences in muscle oxygen oxygenation, expressed as muscle oxygen saturation (SmO2).
Alexandros Stathopoulos, Anatoli Petridou, Nikolaos Kantouris, Vassilis Mougios   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effects of protein supplementation during pilates training on body composition, core muscle endurance, and joint flexibility in trained women: a randomized controlled trial

Journal of the International Society of Sports Nutrition
Background Pilates is a popular type of exercise, aimed at improving core muscle strength and endurance, core stability, and joint flexibility through a variety of whole-body exercises.
Christina Karpouzi, Antigoni Kypraiou, Vassilis Mougios, Anatoli Petridou   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source