Results 71 to 80 of about 2,157,299 (268)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The use of process data in large-scale assessments: a literature review

Large-scale Assessments in Education
As the use of process data in large-scale educational assessments is becoming more common, it is clear that data on examinees’ test-taking behaviors can illuminate their performance, and can have crucial ramifications concerning assessments’ validity.
Ella Anghel, Lale Khorramdel, Matthias von Davier   +2 more
doaj   +1 more source

Exploratory Associations Among Lower-Limb Strength, Selected Isokinetic Knee-Extension Variables, Countermovement Jump Flight Time, and Short-Duration Anaerobic Power in Healthy Male University Students

Applied Sciences
Background: Lower-limb performance is commonly assessed using maximal strength, isokinetic, jump, and anaerobic power tests, but whether these assessments provide overlapping or complementary information in healthy young adults without recent regular ...
Tianqi Zhao, Junwei Xia, JiKwang Ryu, Dohun Kim, Wonil Son   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Field Evaluation of a Human Anthrax Vaccine

American Journal of Public Health and the Nations Health, 1962
IN A SERIES of papers published from 1951-1955,'-" Wright and colleagues, reported on the development of an anthrax vaccine. This vaccine was shown to be an effective immunizing agent for laboratory animals and its safety for human use was demonstrated by the successful injection of 600 scientific personnel at Fort Detrick.
P S, Brachman, H, Gold, S A, Plotkin, F R, Fekety, M, Werrin, N R, Ingraham   +5 more
openaire   +3 more sources

Differences in Physical Indexes between Football Players of Different Playing Positions and Correlation to the Weekly Training Load

Applied Sciences
The aim of this study was twofold: (a) to examine the differences on physical indexes between players of different playing positions and (b) to reveal the correlations between their physical parameters and the running profile within the weekly ...
Lazaros Vardakis, Marianthi Koutsokosta, Yiannis Michailidis, Athanasios Mandroukas, Andreas Stafylidis, Vasilis Kanaras, Charalampos Bamplekis, Andreas Fousekis, Konstantinos Stamatelos, Ioannis Metaxas, Charalambos Zelenitsas, Panagiotis Topalidis, Angelos E. Kyranoudis, Thomas I. Metaxas   +13 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source