Results 251 to 260 of about 3,138,101 (337)

Human lineage mutations regulate RNA-protein binding of conserved genes NTRK2 and ITPR1 involved in human evolution. [PDF]

Gen Psychiatr
Cai W, Song W, Yu S, Zhao M, Lin GN.
europepmc   +1 more source

Use of Erroneous Wolf Generation Time in Assessments of Domestic Dog and Human Evolution

, 2017
L. David Mech
openalex   +1 more source

The Modalization and Evolution of Human Intellect (Cognitive Systems): Following in the Prophets' Footsteps

Fatemeh Khiveh, Omid Asemani, Sedigheh Ebrahimi, Seyed Ziaeddin Tabei, Sekaleshfar Farokh Bahram   +4 more
openalex   +2 more sources

Additional file 13: of Impact of non-LTR retrotransposons in the differentiation and evolution of anatomically modern humans

, 2018
Etienne Guichard, Valentina Peona, Guidantonio Malagoli Tagliazucchi, Lucia Abitante, Evelyn Jagoda, Margherita Musella, Marco Ricci, Alejandro Rubio-RoldĂĄn, Stefania Sarno, Donata Luiselli, Davide Pettener, Cristian Taccioli, Luca Pagani, José L. García-Pérez, Alessio Boattini   +14 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Why we should never do it: stigma as a behaviour change tool in global health

BMJ Global Health, 2019
Amber Wutich, Alexandra Brewis
doaj   +1 more source

Characteristic processes of human evolution caused the Anthropocene and may obstruct its global solutions. [PDF]

Philos Trans R Soc Lond B Biol Sci
Waring TM, Wood ZT, Szathmáry E.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Human Exploration Beyond Low Earth Orbit: Staged Evolution of BLiSS Technologies

Oscar Monje, Ján Fischer, Daniella Saetta, Daniel H. Yeh, Ashley Triana, Luke Roberson   +5 more
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source