Results 281 to 290 of about 3,138,101 (337)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

EVOLUTION OF HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX DRB GENES

, 1995
Yoko Satta, Naoyuki Takahata, J Klein
openalex   +1 more source

Reviewer #2 (Public review): Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

Yao-Chung Chen, Arnaud Maupas, Katja Nowick   +2 more
openalex   +1 more source

Immortal AI, mortal life: long-term perspectives on the evolution rates of artificial intelligence and human intelligence

Hyunjin Shim
openalex   +1 more source

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Human Evolution

2020
This chapter assesses the role of genomics in studying human evolution. Genome sequences tell us how we differ genetically from other apes, fossils fill in details of some of the extinct species, and ancient DNA (aDNA) can even allow us to read their genome sequences.
Lia Chappell, Sarah J Lindsay, Phil Jones, Julian Parkhill, Jonathan Roberts, Nancy Holroyd, Michal Szpak, Francesca Gale   +7 more
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Human Augmentics: Augmenting human evolution

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
Human Augmentics (HA) refers to technologies for expanding the capabilities, and characteristics of humans. One can think of Human Augmentics as the driving force in the non-biological evolution of humans. HA devices will provide technology to compensate for human biological limitations either natural or acquired.
Robert V, Kenyon, Jason, Leigh
openaire   +2 more sources