Results 91 to 100 of about 1,734,834 (239)

Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus. [PDF]

, 2019
BackgroundThe presence of concomitant Type II diabetic mellitus (T2DM) and depressive symptoms adversely affects individuals with symptomatic heart failure (HF).HypothesisIn presymptomatic stage B HF, this study hypothesized the presence of greater ...
Greenberg, Barry H, Lunde, Ottar, Maisel, Alan, Mills, Paul J, Pruitt, Christopher, Pung, Meredith A, Rutledge, Thomas, Taub, Pam R, Wilson, Kathleen   +8 more
core   +1 more source

Asymmetric migration of human keratinocytes under mechanical stretch and cocultured fibroblasts in a wound repair model. [PDF]

PLoS ONE, 2013
Keratinocyte migration during re-epithelization is crucial in wound healing under biochemical and biomechanical microenvironment. However, little is known about the underlying mechanisms whereby mechanical tension and cocultured fibroblasts or ...
Dongyuan Lü, Xiaofeng Liu, Yuxin Gao, Bo Huo, Yingyong Kang, Juan Chen, Shujin Sun, Li Chen, Xiangdong Luo, Mian Long   +9 more
doaj   +1 more source

The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4

Advanced Science
Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1‐catalyzed RNA N7‐methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis.
Shuting Yu, ZhiYong Sun, Tiantian Ju, Yingqi Liu, Zhongting Mei, Changhao Wang, Zhezhe Qu, Na Li, Fan Wu, KuiWu Liu, Meixi Lu, Min Huang, Xiaochen Pang, Yingqiong Jia, Ying Li, Yaozhi Zhang, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Chuanhao Huang, Wanhong Li, Yi zhang, Ye Yuan, Baofeng Yang, Weijie Du   +24 more
doaj   +1 more source

Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart

Biology Open, 2017
Excessive cardiac fibrosis, characterized by increased collagen-rich extracellular matrix (ECM) deposition, is a major predisposing factor for mechanical and electrical dysfunction in heart failure (HF).
Gracious R. Ross, Tanvir Bajwa, Stacie Edwards, Larisa Emelyanova, Farhan Rizvi, Ekhson L. Holmuhamedov, Paul Werner, Francis X. Downey, A. Jamil Tajik, Arshad Jahangir   +9 more
doaj   +1 more source

The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation

Cell Transplantation, 2021
When using human induced pluripotent stem cells (hiPSCs) to achieve hair follicle (HF) replacement, we found it best to emulate the earliest fundamental developmental processes of gastrulation, ectodermal lineage commitment, and dermogenesis.
Michel R. Ibrahim, Walid Medhat, Hasan El-Fakahany, Hamza Abdel-Raouf, Evan Y. Snyder   +4 more
doaj   +1 more source

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources

Transcranial magnetic stimulation as a new tool to control pain perception. [PDF]

, 2015
Treatment for chronic pain is frequently unsuccessful or characterized by side-effects. The high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has been suggested in the management of refractory chronic pain.
Frasca, Vittorio, Gori, MARIA CRISTINA, Inghilleri, Maurizio, Onesti, Emanuela   +3 more
core   +1 more source

Longitudinal associations of leptin and adiponectin with heart rate variability in children [PDF]

, 2017
For early prevention of cardiovascular disease, early detection and risk factor insights are necessary. The autonomic balance reflects cardiovascular risk and can be measured by heart rate variability (HRV).
Michels, Nathalie, Van De Wielle, Roos
core   +3 more sources

Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia

Chinese Medicine
Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with poor overall survival (OS). Resistance to chemotherapeutic drugs such as idarubicin (IDA) remains a major cause of treatment failure.
Liuzhi Shi, Min Zhao, Chen Meng, Min Li, Xuanyu Yu, Shixin Zhang, Shirui Yu, Xinyao Chen, Bin Zhou, Chongyun Xing, Jinjun Jia, Jingying Zhou, Shenmeng Gao   +12 more
doaj   +1 more source

Examining mortality among formerly homeless adults enrolled in Housing First: An observational study [PDF]

, 2015
BACKGROUND: Adults who experience prolonged homelessness have mortality rates 3 to 4 times that of the general population. Housing First (HF) is an evidence-based practice that effectively ends chronic homelessness, yet there has been virtually no ...
Byrne, Thomas H., Henwood, Benjamin F., Scriber, Brynn   +2 more
core   +2 more sources