Results 81 to 90 of about 1,734,834 (239)
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]
, 2014 Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V +3 more
core +2 more sources
Nuclear Factor kappa B is required for the production of infectious human herpesvirus 8 virions
Frontiers in Microbiology, 2014 Human herpesvirus 8 (HHV8) infection leads to potent activation of nuclear factor kappa B (NFB) in primary and transformed cells. We used recombinant HHV8 (rKSHV.219) expressing green fluorescent protein under the constitutive cellular promoter ...
Negin N Blattman +4 more
doaj +1 more source
PLoS ONE, 2022 IntroductionHeart failure (HF) is an increasing global concern. Despite evidence-based pharmacotherapy, morbidity and mortality remain high in HF. Medication non-adherence is a crucial factor in optimising clinical outcomes.
Jessica Chapman-Goetz +7 more
doaj +1 more source
Systems Intelligence and the HF Tool in foregrounding human factors in systemic safety
Theoretical Issues in Ergonomics ScienceThe safety of sociotechnical systems ultimately depends on the success of people’s everyday activities at work. This is the core idea of Safety-II. However, practical tools for applying Safety-II thinking in practice are scarce. In this study we present a new approach to managing human factors (HF) in safety, spotlighting people’s own experiential and ...
Saarinen Esa +3 more
openaire +2 more sources
Journal of Molecular and Cellular Cardiology PlusLeft ventricular (LV) remodeling in heart failure (HF) is associated with vascular rarefaction and impaired angiogenesis. The inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis is a key feature in the pathophysiology of HF ...
Diana Petrova +8 more
doaj +1 more source
Disease Models & Mechanisms, 2012 SUMMARY Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key
Melissa Touvron +9 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2020 Chronic diseases, including heart failure (HF), are often accompanied with skeletal muscle abnormalities in both quality and quantity, which are the major cause of impairment of the activities of daily living and quality of life.
Shingo Takada +3 more
doaj +1 more source
Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair [PDF]
, 2017 High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and
Guilak, Farshid +3 more
core +2 more sources
A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]
, 2017 Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core +1 more source
Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]
, 2016 The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann +3 more
core +3 more sources