Results 61 to 70 of about 25,948,135 (304)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

From capture to inhibition: How does irrelevant information influence visual search? Evidence from a spatial cuing paradigm.

Frontiers in Human Neuroscience, 2016
Even though information is spatially and temporally irrelevant, it can influence the processing of subsequent information. The present study used a spatial cuing paradigm to investigate the origins of this persisting influence by means of event-related ...
Christine eMertes, Edmund eWascher, Daniel eSchneider   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Age-related differences in working memory performance in a 2-back task

Frontiers in Psychology, 2011
The present study aimed to elucidate the neuro-cognitive processes underlying age-related differences in working memory. Young and middle-aged participants performed a two-choice task with low and a 2-back task with high working memory load. The P300, an
Nele eWild-Wall, Michael eFalkenstein, Patrick D. Gajewski   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers

Brain, Behavior, & Immunity - Health
Background: Exhaustion and depersonalization are the core symptoms of the occupational burnout. However, burnout is not an all-or-nothing phenomenon, but can occur in a milder to moderate form in otherwise healthy employees.
Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Carsten Watzl, Edmund Wascher, Stephan Getzmann   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Be prepared for interruptions: EEG correlates of anticipation when dealing with task interruptions and the role of aging

Scientific Reports
Dealing with task interruptions requires the flexible use of working memory and attentional control mechanisms, which are prone to age-related changes.
Soner Ülkü, Stephan Getzmann, Edmund Wascher, Daniel Schneider   +3 more
doaj   +1 more source

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

Cell, 2020
To better understand host-virus genetic dependencies and find potential therapeutic targets for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection of human alveolar ...
Zharko Daniloski, Tristan X. Jordan, H. Wessels, D. Hoagland, S. Kasela, Mateusz Legut, Silas Maniatis, Eleni P. Mimitou, Lu Lu, Evan Geller, Oded Danziger, Brad R. Rosenberg, Hemali Phatnani, Peter Smibert, T. Lappalainen, B. tenOever, Neville E. Sanjana   +16 more
semanticscholar   +1 more source