Results 231 to 240 of about 8,024,974 (292)

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

A Recyclable and Biodegradable High‐Performance Piezoelectric Nanogenerator for Self‐Powered Biosensing and Assistive Human‐Machine Interaction

Advanced Science, EarlyView.
By exploiting multiscale hydrogen‐bonding interactions between HFPD and TOCNF, the composite simultaneously achieves a high piezoelectric coefficient (14.0 pC·N−1), outstanding flexibility (100 000 bending cycles), water‐assisted recyclability, excellent biodegradability, and sensitive wearable/implantable sensing for motion, speech, and Morse code ...
Tingshuai Luo, Tian Xiao, Luyu Zhang, Bailang Zhang, Shengchang Lu, He Xiao, Jianguo Li, Kai Liu, Chaoji Chen, Hui Wu   +9 more
wiley   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Arthropod‐Inspired Miniature Modular Vibration Direct‐Drive Robot With Untethered Locomotion

Advanced Science, EarlyView.
This work presents an arthropod‐inspired untethered miniature modular vibration direct‐drive robot. By utilizing standardized driving units and nested locking interfaces, on‐demand reconfiguration into quadruped, hexapod, octopod, and circular morphologies is achieved.
Shijing Zhang, Ziteng Liu, Youwei Liu, Dehong Wang, Yingxiang Liu   +4 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Architected Load Paths Enable Stiffening and Motion Programming in Soft Pneumatic Actuators

Advanced Science, EarlyView.
A single MARS template introduces an architected reinforcement strategy for programmable soft pneumatic actuators through internal structural organization and selective beam removal. This monolithic architecture enables deformation reconfiguration from continuous bending to joint‐like articulation and torsional motion, allowing one compliant platform ...
Jie Wang, Yuwen Wu, Yuze Zhang, Ye Wei, Yuting Ma, Yingxiang Liu, Kai Guo   +6 more
wiley   +1 more source

Kinematic Analysis of Human Gait in Healthy Young Adults Using IMU Sensors: Exploring Relevant Machine Learning Features for Clinical Applications. [PDF]

Bioengineering (Basel)
Marimon X, Mengual I, López-de-Celis C, Portela A, Rodríguez-Sanz J, Herráez IA, Pérez-Bellmunt A.   +6 more
europepmc   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

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The Signal Gait of the Human

A contrario, 2021
Cet essai rend compte de ma découverte de l’importance de Stanley Cavell. Initialement conçu comme un hommage, ce texte s’avère être plutôt une méditation sur l’enseignement à propos de la lecture, de la lecture de l’autre, et de la lecture de soi par l’autre, que nous pourrions recevoir de Cavell.
openaire   +1 more source