Results 21 to 30 of about 10,524,108 (363)

Genotoxicity of 22% Carbamide Peroxide Bleaching Agent on Oral Cells using the Micronucleus Technique [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Several bleaching products and methods were introduced over the last years. However, the consequences of 22% carbamide peroxide on the genetic material of oral mucosal cells is uncertain.
Laís Vargas Bonacina, Carolina do Amaral Vargas, Julia Vanini, Júlia Zandoná, Rodrigo Rohenkohl Silvlva, Carmen Silvlvia Busin, Paula Benetti, João Paulo De Carli   +7 more
doaj   +1 more source

Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank

medRxiv, 2020
The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a unique private/public partnership between the UK Biobank and eight biopharma companies that will sequence the exomes of all ~500,000 UK Biobank participants.
J. Szustakowski, S. Balasubramanian, A. Sasson, Shareef Khalid, G. Paola, Bronson, E. Kvikstad, E. Wong, Daren Liu, J. Davis, C. Haefliger, A., K. Loomis, Rajesh Mikkilineni, H. J. Noh, Samir Wadhawan, X. Bai, Alicia, Hawes, O. Krasheninina, Ricardo Ulloa, Alexander E. Lopez, Erin N. Smith, Jeffrey Waring, C. Whelan, E. Tsai, J. Overton, W. Salerno, H. Jacob, Sándor, Szalma, H. Runz, Gregory Hinkle, P. Nioi, S. Petrovski, Melissa R. Miller, A. Baras, L. Mitnaul, J. Reid   +38 more
semanticscholar   +1 more source

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Nature Medicine, 2022
The levels of the thousands of metabolites in the human plasma metabolome are strongly influenced by an individual’s genetics and the composition of their diet and gut microbiome.
Lianmin Chen, D. Zhernakova, A. Kurilshikov, S. Andreu-Sánchez, Daoming Wang, Hannah E. Augustijn, A. Vich Vila, R. Weersma, M. Medema, M. Netea, F. Kuipers, C. Wijmenga, A. Zhernakova, Jingyuan Fu   +13 more
semanticscholar   +1 more source

Comparative expression analysis of Shox2-deficient embryonic stem cell-derived sinoatrial node-like cells

Stem Cell Research, 2017
The homeodomain transcription factor Shox2 controls the development and function of the native cardiac pacemaker, the sinoatrial node (SAN). Moreover, SHOX2 mutations have been associated with cardiac arrhythmias in humans.
Sandra Hoffmann, Stefanie Schmitteckert, Anne Griesbeck, Hannes Preiss, Simon Sumer, Alexandra Rolletschek, Martin Granzow, Volker Eckstein, Beate Niesler, Gudrun A. Rappold   +9 more
doaj   +1 more source

Human genetics of meningococcal infections

Human Genetics, 2020
Neisseria meningitidis is a leading cause of bacterial septicaemia and meningitis worldwide. Meningococcal disease is rare but can be life threatening with a tendency to affect children.
Stephanie Hodeib, J. Herberg, M. Levin, V. Sancho-Shimizu   +3 more
semanticscholar   +1 more source

Genetics and Human Malformations [PDF]

Journal of Craniofacial Surgery, 2009
Genetics gains more and more importance in all areas of health care including craniofacial surgery and dentistry. This does not mean that every patient will benefit from genetic advances, but for many health problems, we will see progress in explaining disease pathogenesis, establishing diagnosis, guiding therapy, predicting prognosis, and achieving ...
Gabriele, Mues, Hitesh, Kapadia, Ying, Wang, Rena N, D'Souza   +3 more
openaire   +2 more sources

The Opportunities and Challenges of Integrating Population Histories Into Genetic Studies for Diverse Populations: A Motivating Example From Native Hawaiians

Frontiers in Genetics, 2021
There is a well-recognized need to include diverse populations in genetic studies, but several obstacles continue to be prohibitive, including (but are not limited to) the difficulty of recruiting individuals from diverse populations in large numbers and
Charleston W. K. Chiang, Charleston W. K. Chiang   +1 more
doaj   +1 more source

Human genetics shape the gut microbiome

Cell, 2014
Summary Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear.
Julia Goodrich, Jillian L. Waters, Angela C. Poole, Jessica L. Sutter, O. Koren, R. Blekhman, M. Beaumont, William W. Van Treuren, R. Knight, J. Bell, T. Spector, A. Clark, R. Ley   +12 more
semanticscholar   +1 more source

Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease.

Cell Metabolism, 2020
Fatty liver disease (FLD), including its more severe pathologies, namely steatohepatitis, hepatocarcinoma, and cirrhosis, is the most common cause of chronic liver disease worldwide and is projected to become the leading cause of hepatocellular carcinoma
S. Romeo, A. Sanyal, Luca Valenti
semanticscholar   +1 more source

Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations

HGG Advances, 2023
Summary: Transcriptome prediction models built with data from European-descent individuals are less accurate when applied to different populations because of differences in linkage disequilibrium patterns and allele frequencies.
Daniel S. Araujo, Chris Nguyen, Xiaowei Hu, Anna V. Mikhaylova, Chris Gignoux, Kristin Ardlie, Kent D. Taylor, Peter Durda, Yongmei Liu, George Papanicolaou, Michael H. Cho, Stephen S. Rich, Jerome I. Rotter, Hae Kyung Im, Ani Manichaikul, Heather E. Wheeler   +15 more
doaj   +1 more source