Results 281 to 290 of about 10,781,581 (397)

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Predicting CTCF cell type active binding sites in human genome. [PDF]

Sci Rep
Chai L, Gao J, Li Z, Sun H, Liu J, Wang Y, Zhang L.   +6 more
europepmc   +1 more source

Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation [PDF]

, 1991
Mariel Bedell, John B. Hudson, Todd R. Golub, Mary Turyk, Margaret I. Hosken, George D. Wilbanks, Laimonis A. Laimins   +6 more
openalex   +1 more source

Diverse human genomes [PDF]

Nature Methods, 2020
openaire   +2 more sources

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

SUMMER: an integrated nanopore sequencing pipeline for variants detection and clinical annotation on the human genome. [PDF]

Funct Integr Genomics
Li R, Chu H, Gao K, Luo H, Jiang Y.
europepmc   +1 more source

The human genome contains over a million autonomous exons. [PDF]

Genome Res, 2023
Stepankiw N, Yang AWH, Hughes TR.
europepmc   +1 more source

Type C retrovirus inactivation by human complement is determined by both the viral genome and the producer cell [PDF]

, 1994
Yasuhiro Takeuchi, François–Loïc Cosset, P. J. Lachmann, Hiroshi Okada, Robin A. Weiss, Mary Collins   +5 more
openalex   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Pathogenic signal peptide variants in the human genome. [PDF]

NAR Genom Bioinform, 2023
Gutierrez Guarnizo SA, Kellogg MK, Miller SC, Tikhonova EB, Karamysheva ZN, Karamyshev AL.   +5 more
europepmc   +1 more source