Results 91 to 100 of about 9,795,905 (347)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Optimisation of ASE for Determination of Organic Compounds Bound to Particulate Matter [PDF]

open access: yesKemija u Industriji
Polycyclic aromatic hydrocarbons (PAHs), due to their harmful carcinogenic and mutagenic effects on human health, are significant organic pollutants in the air.
Tajana Horvat   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Directed Evolution of AtMP2 Peptide: Unlocking Enhanced Antibacterial Potential from Anabas testudineus

open access: yesMolecules
Previous studies have shown that AtMP1 and AtMP2, antimicrobial peptides found in the climbing perch (Anabas testudineus), possess antibacterial and anticancer properties.
Li Ting Lee   +8 more
doaj   +1 more source

Environmental risk assessment in a contaminated estuary: an integrated weight of evidence approach as a decision support tool [PDF]

open access: yes, 2017
Environmental risk assessment of complex ecosystems such as estuaries is a challenge, where innovative and integrated approaches are needed. The present work aimed at developing an innovative integrative methodology to evaluate in an impacted estuary ...
Caeiro, Sandra   +9 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Linking the edible plant microbiome and human gut microbiome

open access: yesGut Microbes
The edible plant microbiome, which includes microbes in raw-eaten plants, has been recently recognized as a vehicle delivering microbes to the gut. Fruits and vegetables can carry thousands to billions of microorganisms with diverse genetic capacities on
Gabriele Berg   +4 more
doaj   +1 more source

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