Results 91 to 100 of about 22,629,443 (235)

Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review of Environmental Distribution, Health Impacts, and Regulatory Landscape

Applied Sciences
The widespread production and application of per- and polyfluoroalkyl substances (PFASs) have created a global environmental and public health crisis. This review aimed to consolidate the foundational knowledge on PFASs by synthesizing research on their ...
Elżbieta Dobrzyńska, Paweł Wasilewski, Małgorzata Pośniak   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Quantification of Heavy Metals in Indoor Dust for Health Risk Assessment in Macao

Atmosphere
The presence of heavy metals plays a significant role in indoor air quality, which poses a serious public health problem since most of the population spends over 90% of their time in indoor environments. This work investigates heavy metals in indoor dust
Thomas M. T. Lei, Wenlong Ye, Yuyang Liu, Wan Hee Cheng, Altaf Hossain Molla, L.-W. Antony Chen, Shuiping Wu   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Environmental Occurrence, Influencing Factors, and Toxic Effects of 6PPD-Q

Toxics
The antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is widely incorporated into tires to extend their service life. However, in the presence of ozone, it is readily transformed into N-(1,3-dimethylbutyl)-N′-phenyl-p-benzoquinone ...
Tengwen Yin, Ying Liang, Yanju Liu, Jia Liu, Xuedong Wang   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Development, implementation, and evaluation of interprofessional events on climate change in health professions curricula

Frontiers in Medicine
The threat of climate change and its negative effects on human and planetary health is at the forefront of health organizations around the world. Advocacy to integrate climate change content into health professions education is supported by evidence ...
Kin Ly, Alethea Cariddi, Michelle Cote, Kris Hall   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Inventory update 00 : a regional analysis of health personnel in the province of British Columbia

, 2001
The Cooperative Health Human Resources Database (CHHRD), developed and maintained by the Health Human Resources Unit (HHRU) since 1973, provides the basis for a number of our regular and special reports.
University of British Columbia. Health Human Resources Unit
core   +1 more source