Results 181 to 190 of about 22,629,443 (235)

Cyclitols and Aminocyclitols as Signals: Their Roles in Supporting Ecosystems and Promoting Human Health. [PDF]

J Nat Prod
Skala L, Murdach PK, Hennelly T, Mahmud T.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Impacts of long-term climate change on human health: a global scoping review of quantitative research. [PDF]

BMJ Open
Limaheluw J, Niese R, Bijkerk-Schram D, Hall LF, De Kraker J, Oostdijk SCJ, Serafim F, de Roda Husman AM.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Vaccine-Associated Enhanced Respiratory Disease: From Animal Models to Human Health. [PDF]

Vaccines (Basel)
Dillard JA, Saldivar RA, Heise MT, Baxter VK.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Editorial: The role of essential trace elements in health and disease

Frontiers in Public Health
Dong-Xing Guan, Chunguang Yang, Jerome O. Nriagu   +2 more
doaj   +1 more source

Probiotics: multifunctional microorganisms for human health and biotechnological applications. [PDF]

Front Microbiol
Ali M, Srivastava A, Arora PK.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Chrono-Exercise Medicine: Why Biological Timing Matters for Human Health. [PDF]

Biomedicines
Hesketh SJ.
europepmc   +1 more source