Results 131 to 140 of about 25,956,706 (301)

Protective role of Galectin‐3 in prion disease through regulation of microglial PrPSc uptake

Brain Pathology, EarlyView.
Galectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Natallia Makarava, Tarek Safadi, Narayan P. Pandit, Olga Mychko, Olga Bocharova, Alexey Shevelkin, Kara Molesworth, Marta M. Lipinski, Ilia V. Baskakov   +8 more
wiley   +1 more source

Herpetic infections in humans: modern approaches to etiopathogenetic therapy

Лечащий Врач
Background. Viruses of the Herpesviridae family are DNA-containing viruses prone to latent lifelong persistence in various tissues of the body after primary infection. According to WHO, 64% of people in the world under the age of 50 are infected with the
D. S. Sukhanov, E. V. Timofeev, Yu. S. Alexeeva, S. N. Tretyakov, A. L. Korshunova   +4 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

Interaction between Herpes Virus Infections and IL10 and Risk of Bone Marrow Suppression

International Journal of Organ Transplantation Medicine, 2018
Background: Syndrome of transient bone marrow suppression may result from various extra-hematological diseases, such as immunological deregulations, and viral infectious diseases secondarily affecting the function of hematopoietic stem cells. Objective:
R Yaghobi, F Alizadeh, A Khodavandi
doaj  

Human herpes virus 8-positive germinotropic lymphoproliferative disorder: first case diagnosed in the UK, literature review and discussion of treatment options. [PDF]

BMJ Case Rep, 2020
Ghoneima A, Cooke J, Shaw E, Agrawal A.
europepmc   +1 more source

Long-term impact of acyclovir suppressive therapy on genital and plasma HIV RNA in Tanzanian women: a randomized controlled trial.

, 2010
BACKGROUND: Herpes simplex virus (HSV) suppressive therapy reduces genital and plasma human immunodeficiency virus type 1 (HIV-1) RNA over periods up to 3 months, but the long-term effect is unknown.
Mugeye, Kokugonza, Changalucha, John, Weiss, Helen A, Watson-Jones, Deborah, Tanton, Clare, Hayes, Richard J, Baisley, Kathy, Clayton, Tim C, Rusizoka, Mary, Ross, David A, Everett, Dean, Legoff, Jerome, Belec, Laurent   +12 more
core   +1 more source

A De Novo ATP1A3 p.Arg995His Variant in a Patient With an Adult‐Onset Primary Lateral Sclerosis‐Like Syndrome

Clinical Genetics, EarlyView.
A 43‐year‐old woman developed a progressive adult‐onset upper motor neuron syndrome fulfilling the clinical criteria for primary lateral sclerosis (PLS), with mild cerebellar involvement. Genetic testing identified a de novo ATP1A3 p.Arg995His variant affecting a highly conserved residue within the transmembrane M8 domain.
Pablo Hernandez‐Vitorique, Marta García de Burgos, Ana Campos Villegas, María José Gómez Heredia, Pilar Carbonell Corvillo   +4 more
wiley   +1 more source

The epidemiology of Herpes zoster in an urban population [PDF]

A community-based case-control study was carried out in South London, to investigate the determinants of herpes zoster in adults without underlying immunosuppression.
Thomas, Sara Loraine Monro
core   +1 more source