Oncolytic Virus‐Engineered Extracellular Vesicles Rewire Glioblastoma Immunity
ABSTRACT Immunotherapy with oncolytic Herpes simplex virus type 1 (oHSV‐1) shows promise for glioblastoma; however, clinical benefit remains uncommon due to tumour‐ and host‐mediated immunosuppression, which limits immune targeting of residual glioblastoma stem‐like cells (GSCs). To address this barrier, extracellular vesicles (EVs) harvested from oHSV‐
Klaudia Kiel +18 more
wiley +1 more source
A Pediatric Case of Urinary Retention Caused by Shingles on the Buttocks. [PDF]
Yamada R, Fuchigami T, Moriuchi Y.
europepmc +1 more source
ABSTRACT Cytomegalovirus (CMV) is a prevalent herpesvirus that remains typically asymptomatic in immunocompetent individuals but can cause severe, potentially life‐threatening disease in immunocompromised patients. This study assessed the impact of CMV‐associated lower respiratory tract infections (LRTIs), diagnosed by polymerase chain reaction (PCR ...
Theodora Zouvani +10 more
wiley +1 more source
Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age. [PDF]
Roussy JF +14 more
europepmc +1 more source
The Impact of the HeLa Cell in the Field of Otolaryngology: Honoring Henrietta Lacks
This article provides a scoping review on how the HeLa cell has influenced the field of otolaryngology. Specifically, it discusses how rhinology, otology, laryngology, and head and neck cancer research was influenced by the HeLa cell. We also include a brief review of how HPV was identified in the HeLa cell and how this improved our understanding of ...
Taylor L. Jamil +4 more
wiley +1 more source
Orolabial Herpes Simplex Virus Type 2 Infection: A Case Report Highlighting the Importance of Viral Typing. [PDF]
Chu Y +5 more
europepmc +1 more source
Exploring Cervical Cancer‐Associated Vaginal and Cervical Microbiota via 16S rRNA Sequencing
This 16S sequencing study identified a dysbiotic cervical microbiota (increased diversity, reduced Lactobacillus, enriched Prevotella) specifically linked to high‐risk HPV infection. These microbial alterations, shaped by the HPV‐driven microenvironment, offer novel targets for biomarkers and mechanistic research in cervical carcinogenesis.
Guojiao Wang +5 more
wiley +1 more source
Two Cases of Posner-Schlossman Syndrome With the Detection of Human Herpesvirus 6 DNA in the Aqueous Humor. [PDF]
Fukushima A, Wakuda H, Tabuchi H.
europepmc +1 more source
Posttranslational Modifications of p62/SQSTM1 in Health and Disease
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang +8 more
wiley +1 more source
Organoids: Current Applications and Future Directions
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng +14 more
wiley +1 more source

