Results 51 to 60 of about 2,788,771 (256)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Trust and overreliance on ChatGPT and its implications on critical thinking: an exploration in health policy

Discover Public Health
International organizations have provided guidelines for the use of AI, encouraging its responsible development and promoting human-centered, trust-based use.
Carlos Alberto Rosas-Jiménez, Cynthia Lokker, Bonny Ibhawoh, Lisa Schwartz   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Feasibility study of a screening decision tool for allocating adults into food is medicine programs as an effective approach to target clinical and dietary outcomes among rural and urban adults

Frontiers in Public Health
ObjectiveEvaluate feasibility (primary), clinical, and cost outcomes (secondary) associated with the use of a screening decision tool for allocating rural and urban adults with hypertension into in a food is medicine (FIM) program.DesignParticipants were
Alison Gustafson, Carolyn Lauckner, Joshua L. Bush, Emily Dimond, Carolina Morales Serrano, Christa Mayfield, Elizabeth T. Anderson Steeves   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Advancing implementation science in community settings: the implementation strategies applied in communities (ISAC) compilation

International Journal of Behavioral Nutrition and Physical Activity
Background Implementation strategies have predominantly been operationalized and studied in clinical settings. Implementation strategies are also needed to improve evidence-based intervention (EBI) integration in community settings, but there is a lack ...
Laura E. Balis, Bailey Houghtaling, Whitney Clausen, Hannah Lane, Marilyn E. Wende, Emiliane Pereira, Gabriella M. McLoughlin, Samantha M. Harden   +7 more
doaj   +1 more source

THE PALYNOLOGY CONTRIBUTION IN PALAEOENVIRONMENT INVESTIGATION. A CASE-STUDY OF A LATEGLACIAL-HOLOCENE SEDIMENTARY SEQUENCE NEAR BOLOGNA (NORTHERN ITALY)

EQA, 2017
The palynological studies are extremely relevant in the investigation of the evolution of palaeoenvironments. A case of pedopalynological studies was applied to the Lateglacial to Holocene sedimentary sequence derived from a small site located in San ...
Marco Marchesini, Silvia Marvelli, Antonella Lobietti   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Human Impacts on Holocene Vegetation and Wetland Degradation in the Lower Pearl River, Southern China

Land
Reconstructing Holocene vegetation history and human impact on vegetation is critical for understanding past interactions between humans and nature.
Yaze Zhang, Yanwei Zheng, Qinghua Gong, Shuqing Fu, Cong Chen, Yongjie Tang, Xiao Zhang, Qiuchi Wan, Kangyou Huang, Zhuo Zheng   +9 more
doaj   +1 more source