Results 81 to 90 of about 2,769,323 (258)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The Potential of Manor Gardens for Natural Habitats Conservation

Journal of Landscape Ecology, 2019
Historical gardens established around manors form an integral part of the European cultural landscape. Recent studies have revealed that manor gardens may serve as local hotspots of biodiversity and provide cultural ecosystem services within urban areas ...
Šantrůčková Markéta, Demková Katarína, Dostálek Jiří, Frantík Tomáš   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Indices of human impacts on landscapes: How do they reflect the proportions of natural habitats?

Open Life Sciences
Human activities significantly influence landscapes, altering natural habitats and ecosystem services. This study examines the relationship between human impacts, measured by the hemeroby index and coefficient of anthropogenic impact (CAI´), and the ...
Šantrůčková Markéta, Demková Katarína, Frantík Tomáš, Dostálek Jiří   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Land use in the tropical karst - the case of Peruaçu, Januària and Jaiba; SE Brazil. [PDF]

International Journal of Speleology, 1999
The karstic regions of the municipalities of Peruaçu, Januària and Jaiba present a variety of soil uses which are a function of the organization of the karstic relief.
Kohler Heinz Charles, dos Anjos Ferreira Pinto Sergio, de Abreu Joao Francisco   +2 more
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Biological Activity of Mountain Soils of the Western Caucasus after Deforestation

Лесной журнал
A study of a set of indicators characterizing the ecological state of forest soils in the mountains of the North-Western Caucasus under broad-leaved and mixed forests has been conducted.
Aslan K. Shkhapatsev, Kamil Sh. Kazeev, Yuliya S. Kozun’, Vasily P. Soldatov, Anastasia N. Fedorenko, Valeria V. Vilkova   +5 more
doaj   +1 more source

Quantifying the human impact of Melbourne's 111-day hard lockdown experiment on the adult population. [PDF]

Nat Hum Behav, 2023
Schurer S, Atalay K, Glozier N, Vera-Toscano E, Wooden M.   +4 more
europepmc   +1 more source