Results 61 to 70 of about 87,851 (209)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Trust and overreliance on ChatGPT and its implications on critical thinking: an exploration in health policy

Discover Public Health
International organizations have provided guidelines for the use of AI, encouraging its responsible development and promoting human-centered, trust-based use.
Carlos Alberto Rosas-Jiménez, Cynthia Lokker, Bonny Ibhawoh, Lisa Schwartz   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Feasibility study of a screening decision tool for allocating adults into food is medicine programs as an effective approach to target clinical and dietary outcomes among rural and urban adults

Frontiers in Public Health
ObjectiveEvaluate feasibility (primary), clinical, and cost outcomes (secondary) associated with the use of a screening decision tool for allocating rural and urban adults with hypertension into in a food is medicine (FIM) program.DesignParticipants were
Alison Gustafson, Carolyn Lauckner, Joshua L. Bush, Emily Dimond, Carolina Morales Serrano, Christa Mayfield, Elizabeth T. Anderson Steeves   +6 more
doaj   +1 more source

THE PALYNOLOGY CONTRIBUTION IN PALAEOENVIRONMENT INVESTIGATION. A CASE-STUDY OF A LATEGLACIAL-HOLOCENE SEDIMENTARY SEQUENCE NEAR BOLOGNA (NORTHERN ITALY)

EQA, 2017
The palynological studies are extremely relevant in the investigation of the evolution of palaeoenvironments. A case of pedopalynological studies was applied to the Lateglacial to Holocene sedimentary sequence derived from a small site located in San ...
Marco Marchesini, Silvia Marvelli, Antonella Lobietti   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Advancing implementation science in community settings: the implementation strategies applied in communities (ISAC) compilation

International Journal of Behavioral Nutrition and Physical Activity
Background Implementation strategies have predominantly been operationalized and studied in clinical settings. Implementation strategies are also needed to improve evidence-based intervention (EBI) integration in community settings, but there is a lack ...
Laura E. Balis, Bailey Houghtaling, Whitney Clausen, Hannah Lane, Marilyn E. Wende, Emiliane Pereira, Gabriella M. McLoughlin, Samantha M. Harden   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Human Impacts on Holocene Vegetation and Wetland Degradation in the Lower Pearl River, Southern China

Land
Reconstructing Holocene vegetation history and human impact on vegetation is critical for understanding past interactions between humans and nature.
Yaze Zhang, Yanwei Zheng, Qinghua Gong, Shuqing Fu, Cong Chen, Yongjie Tang, Xiao Zhang, Qiuchi Wan, Kangyou Huang, Zhuo Zheng   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source