Results 241 to 250 of about 18,071,962 (296)
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
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2021
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush +3 more
openaire +1 more source
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush +3 more
openaire +1 more source
Science
Behind the myriad upheavals U.S. science has faced during the first 100 days of President Donald Trump’s administration, countless researchers are fighting for their careers and aspirations.
Sara, Reardon +3 more
openaire +2 more sources
Behind the myriad upheavals U.S. science has faced during the first 100 days of President Donald Trump’s administration, countless researchers are fighting for their careers and aspirations.
Sara, Reardon +3 more
openaire +2 more sources
1992
Abstract Environmental change spans all of human time. Even so-called primitive peoples have left their mark on the earth. Fire, the oldest of anthropogenic landscape modifiers, has long been implicated in the origins and maintenance of tropical savannahs and mid-latitude grasslands, and biggame hunters of the Stone Age may have caused ...
S Robert Aiken, Colin H Leigh
openaire +1 more source
Abstract Environmental change spans all of human time. Even so-called primitive peoples have left their mark on the earth. Fire, the oldest of anthropogenic landscape modifiers, has long been implicated in the origins and maintenance of tropical savannahs and mid-latitude grasslands, and biggame hunters of the Stone Age may have caused ...
S Robert Aiken, Colin H Leigh
openaire +1 more source
Telepresence Robots and Their Impact on Human-Human Interaction
2020In an increasingly globalized world remote communication becomes ever more crucial. Hence, telepresence robots gain importance as they simplify attending important but distant events. However, research regarding human affinity towards a person by interacting directly or through a telepresence robot with another individual has not been undertaken ...
Lisa Keller +3 more
openaire +2 more sources
1985
The fundamental role of climate for the fate of mankind is increasingly being recognized at both the international and national levels (World Meteorological Organization, 1980, pp. 7–10, 28–37; World Meteorological Organization-ICSU, 1975, pp. 1–3; United Nations Environment Programme, 1979, pp. 1–16; National Climate Program Office NOAA, 1980, pp. 1–4,
openaire +1 more source
The fundamental role of climate for the fate of mankind is increasingly being recognized at both the international and national levels (World Meteorological Organization, 1980, pp. 7–10, 28–37; World Meteorological Organization-ICSU, 1975, pp. 1–3; United Nations Environment Programme, 1979, pp. 1–16; National Climate Program Office NOAA, 1980, pp. 1–4,
openaire +1 more source