Results 91 to 100 of about 18,071,962 (296)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Potential of Manor Gardens for Natural Habitats Conservation

Journal of Landscape Ecology, 2019
Historical gardens established around manors form an integral part of the European cultural landscape. Recent studies have revealed that manor gardens may serve as local hotspots of biodiversity and provide cultural ecosystem services within urban areas ...
Šantrůčková Markéta, Demková Katarína, Dostálek Jiří, Frantík Tomáš   +3 more
doaj   +1 more source

Thinking About my Impact and Engagement: A Worksheet

What does making positive societal impact mean to you? How do you map current and potential partners and beneficiaries? How to align your work to their needs? This workshop package offers a brief printable worksheet with accompanying presentation slides,
Evaluating Societal Impact
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Indices of human impacts on landscapes: How do they reflect the proportions of natural habitats?

Open Life Sciences
Human activities significantly influence landscapes, altering natural habitats and ecosystem services. This study examines the relationship between human impacts, measured by the hemeroby index and coefficient of anthropogenic impact (CAI´), and the ...
Šantrůčková Markéta, Demková Katarína, Frantík Tomáš, Dostálek Jiří   +3 more
doaj   +1 more source

Human Impacts on Atmospheric Chemistry

Annual Review of Earth and Planetary Sciences, 2001
An overview is given of the main anthropogenic influences on the chemistry of the atmosphere. Industrial and agricultural activities have altered the chemical composition of the atmosphere in many important ways, which is reflected especially in the distribution and concentrations of ozone in the troposphere and stratosphere.
Crutzen, P.J., Lelieveld, J.
openaire   +4 more sources

Impact Strategy Development: Discovering your Current Organisational Landscape

This tool guides the research process of discovering a school’s organisational impact landscape as one of the steps when developing an impact strategy.
Evaluating Societal Impact
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Land use in the tropical karst - the case of Peruaçu, Januària and Jaiba; SE Brazil. [PDF]

International Journal of Speleology, 1999
The karstic regions of the municipalities of Peruaçu, Januària and Jaiba present a variety of soil uses which are a function of the organization of the karstic relief.
Kohler Heinz Charles, dos Anjos Ferreira Pinto Sergio, de Abreu Joao Francisco   +2 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source