Results 71 to 80 of about 87,851 (209)

Human-triggered earthquakes and their impacts on human security [PDF]

Nature Precedings, 2010
AbstractA comprehensive understanding of earthquake risks in urbanized regions requires an accurate assessment of both urban vulnerabilities and earthquake hazards. Socioeconomic risks associated with human-triggered earthquakes are often misconstrued and receive little scientific, legal, and public attention.
openaire   +4 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Antropojenik Jeomorfoloji Yaklaşımı İle Topografyadaki İnsan Etkisinin Modellenmesi: Muğla İlinin Kuzeybatı Sahası Örneği

Dünya Coğrafyası ve Kalkınma Perspektifi Dergisi
İnsan faaliyetlerinin doğal koşullardaki baskı ve etki boyutlarının artması, jeomorfolojik unsurlarda da değişimlere yol açmaktadır. Bu çalışmada Muğla ilinin kuzey ve batısındaki 6 ilçe kapsamında zamansal ve mekânsal açıdan farklı kriterler ...
Selin Apatarkan, Kadir Tatlıdil, Murat Uzun   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Rewiring the Evaluation Marketplace for a Changing World

Journal of MultiDisciplinary Evaluation
This issue of JMDE asks how evaluation should respond to the transformational imperative to contribute to the radical changes essential for a regenerative, socially just, and equitable future for humanity and the planet.
Nancy MacPherson, Thomas Kelly, A. K. Shiva Kumar   +2 more
doaj  

Impact of river engineering on Vistula river channel morphometry near Warsaw (Poland): a 172-year perspective

Miscellanea Geographica: Regional Studies on Development
This study investigates the impact of river engineering on the morphometry of the Vistula River channel near Warsaw, Poland, over a 172-year period. This research focuses on the examination of modifications in the Vistula channel between 1843 and 2015 ...
Poławska Martyna, Giriat Dorota
doaj   +1 more source

Determinants of change in the duration of ice phenomena on the Vistula River in Toruń

Journal of Hydrology and Hydromechanics, 2015
Winter season temperatures are becoming warmer. However, the transformation of the ice regime on the Vistula River in Toruń has also been affected by river engineering.
Pawłowski Bogusław
doaj   +1 more source