Results 151 to 160 of about 2,774,595 (256)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Capturing the human impact of living with multiple long-term conditions in routine electronic health records - lost in translation? [PDF]

J Multimorb Comorb
Fraser SDS, Holland E, Laidlaw L, Francis NA, Macdonald S, Mair FS, Alwan NA, Boniface M, Hoyle RB, Fair N, Dylag JJ, Shiranirad M, Chiovoloni R, Stannard S, Poole R, Akbari A, Ashworth M, Dregan A.   +17 more
europepmc   +1 more source

Fox dietary ecology as a tracer of human impact on Pleistocene ecosystems. [PDF]

PLoS One, 2020
Baumann C, Bocherens H, Drucker DG, Conard NJ.   +3 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Integrating seasonal dynamics and human impact on microbial biomass carbon across deep soil profiles in tropical Sal forest of Achanakmar-Amarkantak Biosphere Reserve, India. [PDF]

Sci Rep
Singh S, Dixit B, Singh A, Prajapati L, Chandrakar S, Tamrakar A.   +5 more
europepmc   +1 more source

The human impact on North American erosion, sediment transfer, and storage in a geologic context. [PDF]

Nat Commun, 2020
Kemp DB, Sadler PM, Vanacker V.
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Montane rainforest dynamics under changes in climate and human impact during the past millennia in northern Madagascar. [PDF]

R Soc Open Sci
Montade V, Bremond L, Teixeira H, Kasper T, Daut G, Rouland S, Rasoamanana E, Ramavovolona P, Favier C, Arnaud F, Radespiel U, Behling H.   +11 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Human Impact on the Twenty-Four-Hour Patterns of Steller Sea Lions' Use of a Haulout in Hokkaido, Japan. [PDF]

Animals (Basel)
Chayahara Y, Nakanowataru Y, Abe S, Kurosawa R, Suma S, Murasato N, Oyamada R, Ebashi N, Tsunokawa M, Sakurama M, Kooriyama T.   +10 more
europepmc   +1 more source