Results 141 to 150 of about 2,774,595 (256)

Complex Variation in Afrotropical Mammal Communities With Human Impact. [PDF]

Ecol Evol
Tuyisingize D, Kulik L, Assou D, Zausa D, Kamga S, Mundi O, Heinicke S, Kone I, Mucyo SJP, Sop T, Boesch C, Stephens C, Agbor A, Angedakin S, Bailey E, Bessone M, Coupland C, Head J, Deschner T, Dieguez P, Egbe VE, Granjon AC, Hicks TC, Jones S, Kalan AK, Langergraber KE, Lapuente J, Lee KC, Lynn LK, Maldonado N, McCarthy MS, Meier A, Ormsby LJ, Piel AK, Sciaky L, Sommer V, Stewart FA, Wessling EG, Widness J, Wittig RM, Strohbach P, Arandjelovic M, van der Hoek Y, Kühl HS.   +43 more
europepmc   +1 more source

The past and future human impact on mammalian diversity. [PDF]

Sci Adv, 2020
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Rapid development of an online tracker to communicate the human impact of abruptly halting PEPFAR support. [PDF]

J Int AIDS Soc
Nichols BE, Geng EH, Moakley E, Phillips AN, Imai-Eaton JW, Stover J, Mudimu E, Grimsrud A.   +7 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

8,000 years of wild and domestic animal body size data reveal long-term synchrony and recent divergence due to intensified human impact. [PDF]

Proc Natl Acad Sci U S A
Mureau C, d'Oliveira L, Peyron O, Blaise E, Renaud A, Balcarcel A, Jeanjean M, Bonhomme V, Bouby L, Ros J, Evin A.   +10 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

MultiAgency, prospective, exploratory, non-intervention, cohort Study on Human Impact Exposure oNboard high-speed boats (MASHIEN): protocol. [PDF]

BMJ Open
Ullman J, Myers SD, Bretschneider KT, Kelly KR, Daniel Y, Hurpin V, Kaehler J, Kåsin JI, Hveding K, Mansfield N, Masouros SD, Perl D, Wijnands N, Vallee I, Stevens V, Fraser JJ, Rolfson O, Robinson Y.   +17 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source