Results 81 to 90 of about 2,872,047 (257)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Potential of Manor Gardens for Natural Habitats Conservation
Journal of Landscape Ecology, 2019 Historical gardens established around manors form an integral part of the European cultural landscape. Recent studies have revealed that manor gardens may serve as local hotspots of biodiversity and provide cultural ecosystem services within urban areas ...
Šantrůčková Markéta +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Indices of human impacts on landscapes: How do they reflect the proportions of natural habitats?
Open Life SciencesHuman activities significantly influence landscapes, altering natural habitats and ecosystem services. This study examines the relationship between human impacts, measured by the hemeroby index and coefficient of anthropogenic impact (CAI´), and the ...
Šantrůčková Markéta +3 more
doaj +1 more source
Human Impacts on Atmospheric Chemistry
Annual Review of Earth and Planetary Sciences, 2001 An overview is given of the main anthropogenic influences on the chemistry of the atmosphere. Industrial and agricultural activities have altered the chemical composition of the atmosphere in many important ways, which is reflected especially in the distribution and concentrations of ozone in the troposphere and stratosphere.
Crutzen, P.J., Lelieveld, J.
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Land use in the tropical karst - the case of Peruaçu, Januària and Jaiba; SE Brazil. [PDF]
International Journal of Speleology, 1999 The karstic regions of the municipalities of Peruaçu, Januària and Jaiba present a variety of soil uses which are a function of the organization of the karstic relief.
Kohler Heinz Charles +2 more
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Biological Activity of Mountain Soils of the Western Caucasus after Deforestation
Лесной журналA study of a set of indicators characterizing the ecological state of forest soils in the mountains of the North-Western Caucasus under broad-leaved and mixed forests has been conducted.
Aslan K. Shkhapatsev +5 more
doaj +1 more source