Results 161 to 170 of about 8,175,458 (300)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Environmental security as a criterion for sustainable development in Western Siberia

RUDN Journal of Ecology and Life Safety, 2009
The article discusses the criteria of environmental safety as one of indicators of sustainable development of society. A description of the environmental situation in Western Siberia, identifiedenvironmental hazard.
O V Udartseva
doaj  

Correction to: Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway. [PDF]

PNAS Nexus, 2023
europepmc   +1 more source

Determination of the human impact on the drop in NO₂ air pollution due to total COVID-19 lockdown using Human-Influenced Air Pollution Decrease Index (HIAPDI). [PDF]

Environ Pollut, 2022
Kovács KD.
europepmc   +1 more source

Accumulation of Human Capital and FDI Inflows in ASEAN-3 Countries (Malaysia, Thailand, Indonesia) [PDF]

The event of globalization and the increasing inflows of FDI to developing countries create a potential for technology transfers and spillovers which suggest a potential for future growth of human capital, and output.
Heirsh SOLTANPANAH, Mohammad Sharif KARIMI   +1 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The global human impact on biodiversity. [PDF]

Nature
Keck F, Peller T, Alther R, Barouillet C, Blackman R, Capo E, Chonova T, Couton M, Fehlinger L, Kirschner D, Knüsel M, Muneret L, Oester R, Tapolczai K, Zhang H, Altermatt F.   +15 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Complex Variation in Afrotropical Mammal Communities With Human Impact. [PDF]

Ecol Evol
Tuyisingize D, Kulik L, Assou D, Zausa D, Kamga S, Mundi O, Heinicke S, Kone I, Mucyo SJP, Sop T, Boesch C, Stephens C, Agbor A, Angedakin S, Bailey E, Bessone M, Coupland C, Head J, Deschner T, Dieguez P, Egbe VE, Granjon AC, Hicks TC, Jones S, Kalan AK, Langergraber KE, Lapuente J, Lee KC, Lynn LK, Maldonado N, McCarthy MS, Meier A, Ormsby LJ, Piel AK, Sciaky L, Sommer V, Stewart FA, Wessling EG, Widness J, Wittig RM, Strohbach P, Arandjelovic M, van der Hoek Y, Kühl HS.   +43 more
europepmc   +1 more source