Results 171 to 180 of about 8,175,458 (300)

The past and future human impact on mammalian diversity. [PDF]

Sci Adv, 2020
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D.   +4 more
europepmc   +1 more source

Immigration and Human Development: Evidence from Lebanon [PDF]

This paper takes Lebanon as a case study to examine the relationship between human development and immigration. It examines this issue from both ends: the sending and the receiving countries.
Paul Tabar
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Rapid development of an online tracker to communicate the human impact of abruptly halting PEPFAR support. [PDF]

J Int AIDS Soc
Nichols BE, Geng EH, Moakley E, Phillips AN, Imai-Eaton JW, Stover J, Mudimu E, Grimsrud A.   +7 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

MultiAgency, prospective, exploratory, non-intervention, cohort Study on Human Impact Exposure oNboard high-speed boats (MASHIEN): protocol. [PDF]

BMJ Open
Ullman J, Myers SD, Bretschneider KT, Kelly KR, Daniel Y, Hurpin V, Kaehler J, Kåsin JI, Hveding K, Mansfield N, Masouros SD, Perl D, Wijnands N, Vallee I, Stevens V, Fraser JJ, Rolfson O, Robinson Y.   +17 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Capturing the human impact of living with multiple long-term conditions in routine electronic health records - lost in translation? [PDF]

J Multimorb Comorb
Fraser SDS, Holland E, Laidlaw L, Francis NA, Macdonald S, Mair FS, Alwan NA, Boniface M, Hoyle RB, Fair N, Dylag JJ, Shiranirad M, Chiovoloni R, Stannard S, Poole R, Akbari A, Ashworth M, Dregan A.   +17 more
europepmc   +1 more source