Results 141 to 150 of about 2,872,047 (257)

Phytosociological analysis and floristic composition of fabaceae species assessing human impact and edaphic variables. [PDF]

Sci Rep
Majeed M, Khan A, Saleem S, Zaman W, Ali HE, Khan MS, Alrefaei AF, Mahmood N.   +7 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Correction to: Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway. [PDF]

PNAS Nexus, 2023
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The global human impact on biodiversity. [PDF]

Nature
Keck F, Peller T, Alther R, Barouillet C, Blackman R, Capo E, Chonova T, Couton M, Fehlinger L, Kirschner D, Knüsel M, Muneret L, Oester R, Tapolczai K, Zhang H, Altermatt F.   +15 more
europepmc   +1 more source

Determination of the human impact on the drop in NO₂ air pollution due to total COVID-19 lockdown using Human-Influenced Air Pollution Decrease Index (HIAPDI). [PDF]

Environ Pollut, 2022
Kovács KD.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Complex Variation in Afrotropical Mammal Communities With Human Impact. [PDF]

Ecol Evol
Tuyisingize D, Kulik L, Assou D, Zausa D, Kamga S, Mundi O, Heinicke S, Kone I, Mucyo SJP, Sop T, Boesch C, Stephens C, Agbor A, Angedakin S, Bailey E, Bessone M, Coupland C, Head J, Deschner T, Dieguez P, Egbe VE, Granjon AC, Hicks TC, Jones S, Kalan AK, Langergraber KE, Lapuente J, Lee KC, Lynn LK, Maldonado N, McCarthy MS, Meier A, Ormsby LJ, Piel AK, Sciaky L, Sommer V, Stewart FA, Wessling EG, Widness J, Wittig RM, Strohbach P, Arandjelovic M, van der Hoek Y, Kühl HS.   +43 more
europepmc   +1 more source

The past and future human impact on mammalian diversity. [PDF]

Sci Adv, 2020
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source