Results 241 to 250 of about 8,175,458 (300)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
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2021
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush +3 more
openaire +1 more source
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush +3 more
openaire +1 more source
Science
Behind the myriad upheavals U.S. science has faced during the first 100 days of President Donald Trump’s administration, countless researchers are fighting for their careers and aspirations.
Sara, Reardon +3 more
openaire +2 more sources
Behind the myriad upheavals U.S. science has faced during the first 100 days of President Donald Trump’s administration, countless researchers are fighting for their careers and aspirations.
Sara, Reardon +3 more
openaire +2 more sources
1992
Abstract Environmental change spans all of human time. Even so-called primitive peoples have left their mark on the earth. Fire, the oldest of anthropogenic landscape modifiers, has long been implicated in the origins and maintenance of tropical savannahs and mid-latitude grasslands, and biggame hunters of the Stone Age may have caused ...
S Robert Aiken, Colin H Leigh
openaire +1 more source
Abstract Environmental change spans all of human time. Even so-called primitive peoples have left their mark on the earth. Fire, the oldest of anthropogenic landscape modifiers, has long been implicated in the origins and maintenance of tropical savannahs and mid-latitude grasslands, and biggame hunters of the Stone Age may have caused ...
S Robert Aiken, Colin H Leigh
openaire +1 more source
1999
For eons the global environment of the planet has shaped the biosphere, and has been in turn shaped by the biosphere. According to the Gaia hypothesis, the overall impact of the biosphere on the global environment has been beneficial for the development and sustenance of life.
Yuk L. Yung, William B. DeMore
openaire +1 more source
For eons the global environment of the planet has shaped the biosphere, and has been in turn shaped by the biosphere. According to the Gaia hypothesis, the overall impact of the biosphere on the global environment has been beneficial for the development and sustenance of life.
Yuk L. Yung, William B. DeMore
openaire +1 more source