Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Need for Human Services in Illinois [PDF]
, 2011 This report aims to support the Illinois Human Services Commission in its effort to fulfill its charge to "undertake a systematic review of human services programs with the goal of ensuring their consistent delivery in the State of Illinois" and to "make
Amy Terpstra, Ellyn Drathring
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Human capital—economic growth nexus in the former Soviet Bloc [PDF]
This study analyses the role of education in economic development in the republics of the former Socialist Bloc and more specifically the impact of human capital on per capita economic growth in transition economies in the Russian Federation, and Ukraine.
Osipian, Ararat
core +1 more source
A Smart Investment in Human Capital: How AchieveMission Helped the Corporation for Supportive Housing Increase Mission Impact [PDF]
, 2013 This report examines the work of AcheiveMission as it helped The Corporation for Supportive Housing to completely re-think how it attracts, places, supports and key staff and manages human capital to improve mission ...
core
The Impact of the Criminalization of HIV Non-Disclosure on the Health and Human Rights of “Black” Communities [PDF]
, 2013 The criminalization of HIV non-disclosure has become a hot topic for discussion and debate amongst human rights advocates, HIV/AIDS service providers, and people infected and affected by HIV/AIDS.
Wilson, Ciann L.
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Nepal: Earthquake Recovery Must Safeguard Human Rights [PDF]
, 2015 This briefing highlights some important areas of concern which Amnesty International believes could have an impact on the success of relief and reconstruction endeavours in Nepal.Protection and respect for human rights has been severely weakened by Nepal'
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Paying for Overhead: A Study of the Impact of Foundations' Overhead Payment Policies on Educational and Human Service Organizations [PDF]
, 2007 Examines the impact of foundations' overhead funding policies on educational and human services organizations, using data from two original surveys and six case ...
Heidi K. Frederick, Patrick Rooney
core +1 more source