Results 31 to 40 of about 578,251 (255)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Looking at the big picture: demonstrating benefits of Bayesian latent cluster spatio-temporal analysis for understanding maternal prescription opioids misuse

BMC Public Health
Background As the opioid crisis rages, maternal prescription opioid misuse (MPOM) is particularly concerning because it influences both the mother and child’s wellbeing. However, little was known about the trend of MPOM and its county-level risk factors.
Xueyi Xing, D. Max Crowley, Christian M. Connell   +2 more
doaj   +1 more source

Multiparameter analysis of Diuron and its metabolites (DCA and DCPMU) in different stages of zebrafish (Danio rerio) development

Frontiers in Water
IntroductionDiuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a prominent herbicide in Brazilian agriculture, particularly in sugarcane farming. This herbicide persists in the environment and is transformed into potentially toxic metabolites, such as 3,
Paloma Vitória Lima Peixoto, Bianca Camargo Penteado Sales, Luiza Aggio, Cristina Viriato, Lilian Cristina Pereira   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

BMI or not to BMI? debating the value of body mass index as a measure of health in adults

International Journal of Behavioral Nutrition and Physical Activity
Body mass index (BMI) is used across public health to calculate height to weight ratio and translate into weight status. Whether BMI is appropriate as an individual- or population-level health measure for adults is debated.
Carmen Byker Shanks, Meg Bruening, Amy L. Yaroch   +2 more
doaj   +1 more source

The power of lived experience in optimizing US policymakers’ engagement with substance use research: A series of rapid-cycle randomized controlled trials

Drug and Alcohol Dependence Reports
Background: Research can inform policies on substance use/substance use disorders (SU/SUDs), yet there is limited experimental investigation into strategies for optimizing policymakers’ engagement with SU/SUD research.
Elizabeth C. Long, Riley Loria, Jessica Pugel, Patrick O’Neill, Camille C. Cioffi, Charleen Hsuan, Glenn Sterner, D. Max Crowley, J. Taylor Scott   +8 more
doaj   +1 more source

Microbial Communities in Permafrost Soils of Larsemann Hills, Eastern Antarctica: Environmental Controls and Effect of Human Impact

Microorganisms, 2020
Although ice-free areas cover only about 0.1% of Antarctica and are characterized by harsh environmental conditions, these regions provide quite diverse conditions for the soil-forming process, having various physical and geochemical properties, and also
Ivan Alekseev, Aleksei Zverev, Evgeny Abakumov   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Ecogeomorphology and vulnerability in a Mediterranean ria-type coast (La Maddalena Archipelago, NE Sardinia, western Mediterranean)

Journal of Maps, 2021
This paper presents a map describing the main geomorphological and sedimentological features, hydrodynamics, benthic habitat distributions and human impact on the coastal and marine areas of the Archipelago of La Maddalena (NE Sardinia, western ...
Sandro De Muro, Carla Buosi, Manuela Biondo, Angelo Ibba, Andrea Ruju, Daniele Trogu, Marco Porta   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source