Results 51 to 60 of about 578,251 (255)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The impact of healthcare on global warming and human health: connecting the dots [PDF]
, 2017 The aim of this paper is to explore climate change and the impact that this is having on human health. The paper takes the reader through a brief history of climate change, making links between raising global temperatures and the environmental effects ...
Fernandez, A., Griggs, C., Callanan, M.
core
Ribogospodarsʹka Nauka Ukraïni, 2019 Purpose. To establish the nature of changes in physiological and biochemical parameters of fish, the qualitative and quantitative composition of their parasitocenoses, depending on the degree of the pollution of water bodies. Methodology.
Ju. Kovalenko +3 more
doaj +1 more source
Historical Introduction of Japanese Wild Mice, Mus musculus, from South China and the Korean Peninsula [PDF]
Animal Systematics, Evolution and Diversity, 2013 In Japan, the wild house mouse Mus musculus consists of two lineages, one from Southeast Asia (Mus musculus castaneus; CAS) and one from northern Eurasia (Mus musculus musculus; MUS). However, the exact origins of the parental lineages are unclear.
Mitsuo Nunome +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Embryotoxicity Induced by Triclopyr in Zebrafish (Danio rerio) Early Life Stage
ToxicsTriclopyr, an auxin-like herbicide that is widely employed for managing weeds in food crops and pastures, has been identified in various environmental settings, particularly aquatic ecosystems.
Ítalo Bertoni +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2020 This community based human rights impact assessment highlights the social, environmental, cultural, and human rights risks of the East African Crude Oil pipeline for communities located along the proposed pipeline corridor in Uganda and ...
Bogrand, Andrew +6 more
core +1 more source
Frontiers in Microbiology, 2019 Archaea play vital roles in global biogeochemical cycles, particularly in nitrification and methanogenesis. The recovery of archaeal community following disturbance is essential for maintaining the stability of ecosystem function.
Yu Wang +7 more
doaj +1 more source