Results 81 to 90 of about 578,251 (255)

Work-life balance: the impact of policy and practice on the human resource function

open access: yes, 2005
As organizations increasingly become subjected to the forces of globalization, pressure to increase competitiveness and with it the demands on people to serve their businesses with drive and commitment become even stronger.
Shortland, S.
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Geostatistical analisys on the relationship between vegetation pattern and human impact

open access: yes, 2009
The purpose of this work is to evaluate the vegetation pattern of a mediterranean landscape, analyzed through the shape of the patches that constitute it, and its relationship with alterations introduced by land use and human impact. As a case of study
SCHICCHI, Rosario   +2 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Globalization and its impact on human rights [PDF]

open access: yes
The present study explores the nuanced interaction of globalization and human rights. Globalization has significantly transformed political, cultural and economic rights, resulting in various dynamic results that have implications for different human ...
Hosamani, Swathi K.   +1 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Impact of river engineering on Vistula river channel morphometry near Warsaw (Poland): a 172-year perspective

open access: yesMiscellanea Geographica: Regional Studies on Development
This study investigates the impact of river engineering on the morphometry of the Vistula River channel near Warsaw, Poland, over a 172-year period. This research focuses on the examination of modifications in the Vistula channel between 1843 and 2015 ...
Poławska Martyna, Giriat Dorota
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Determinants of change in the duration of ice phenomena on the Vistula River in Toruń

open access: yesJournal of Hydrology and Hydromechanics, 2015
Winter season temperatures are becoming warmer. However, the transformation of the ice regime on the Vistula River in Toruń has also been affected by river engineering.
Pawłowski Bogusław
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy