Results 101 to 110 of about 2,788,771 (256)

Early human impact on lake cyanobacteria revealed by a Holocene record of sedimentary ancient DNA. [PDF]

Commun Biol, 2023
Nwosu EC, Brauer A, Monchamp ME, Pinkerneil S, Bartholomäus A, Theuerkauf M, Schmidt JP, Stoof-Leichsenring KR, Wietelmann T, Kaiser J, Wagner D, Liebner S.   +11 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway. [PDF]

PNAS Nexus, 2022
Brown T, Rijal DP, Heintzman PD, Clarke CL, Blankholm HP, Høeg HI, Lammers Y, Bråthen KA, Edwards M, Alsos IG.   +9 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Human impacts [PDF]

Nature Climate Change, 2015
openaire   +2 more sources

Correction: Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]

BMC Genomics, 2023
Nieto-Blázquez ME, Schreiber D, Mueller SA, Koch K, Nowak C, Pfenninger M.   +5 more
europepmc   +1 more source

Impact of Human Vulnerabilities on Cybersecurity [PDF]

Computer Systems Science and Engineering, 2022
Maher Alsharif, Shailendra Mishra, Mohammed Alshehri   +2 more
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The human impact of commercial delivery cycling injuries: a pilot retrospective cohort study. [PDF]

Pilot Feasibility Stud, 2022
Sarkies MN, Hemmert C, Pang YC, Shiner CT, McDonell K, Mitchell R, Lystad RP, Novy M, Christie LJ.   +8 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source