Results 141 to 150 of about 17,376,473 (292)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]

BMC Genomics, 2022
Nieto-Blázquez ME, Schreiber D, Mueller SA, Koch K, Nowak C, Pfenninger M.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Community Essay: Sustainability science – and what’s needed beyond science

Sustainability: Science, Practice, & Policy, 2005
Educating broadly about the science and technologies of sustainability is essential, because it convinces us that a successfully sustainable future is being undermined.
Paul H. Reitan
doaj  

The Human Impact on All Soil-Forming Factors during the Anthropocene. [PDF]

ACS Environ Au, 2022
Dror I, Yaron B, Berkowitz B.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ancient environmental DNA indicates limited human impact on marine biodiversity in pre-industrial Iceland. [PDF]

Philos Trans R Soc Lond B Biol Sci
Holman LE, Arfaoui EMR, Pedersen LB, Farnsworth WR, Ascough P, Butler P, Guðmundsdóttir ER, Reynolds DJ, Trofimova T, Wilkin JTR, Carøe C, Frøslev TG, Harrison R, Gopalakrishnan S, Pedersen MW, Scourse J, Bohmann K.   +16 more
europepmc   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Impact: health and welfare division report 2003-2005

, 2006
IMPACT members gave a massive endorsement to the Sustaining Progress national deal in March 2003, when they backed it by 9-1 in a national bailout entitled all workers to pay increases worth a total of seven per cent in the first 18 months of the ...
IMPACT
core  

Stakeholder Mapping Guide

This resource is a (non-exhaustive) collection of materials on stakeholder mapping, analysis, and engagement, based on the experiences and insights of the Evaluating Societal Impact team.
Evaluating Societal Impact
core   +1 more source