Results 111 to 120 of about 2,769,848 (257)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Ancient environmental DNA indicates limited human impact on marine biodiversity in pre-industrial Iceland. [PDF]

Philos Trans R Soc Lond B Biol Sci
Holman LE, Arfaoui EMR, Pedersen LB, Farnsworth WR, Ascough P, Butler P, Guðmundsdóttir ER, Reynolds DJ, Trofimova T, Wilkin JTR, Carøe C, Frøslev TG, Harrison R, Gopalakrishnan S, Pedersen MW, Scourse J, Bohmann K.   +16 more
europepmc   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Community Essay: Sustainability science – and what’s needed beyond science

Sustainability: Science, Practice, & Policy, 2005
Educating broadly about the science and technologies of sustainability is essential, because it convinces us that a successfully sustainable future is being undermined.
Paul H. Reitan
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Pattern and pace of morphological change due to variable human impact: the case of Japanese macaques. [PDF]

Primates, 2021
Geiger M.
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Past environmental changes affected lemur population dynamics prior to human impact in Madagascar. [PDF]

Commun Biol, 2021
Teixeira H, Montade V, Salmona J, Metzger J, Bremond L, Kasper T, Daut G, Rouland S, Ranarilalatiana S, Rakotondravony R, Chikhi L, Behling H, Radespiel U.   +12 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Rapid expansion of human impact on natural land in South America since 1985. [PDF]

Sci Adv, 2021
Zalles V, Hansen MC, Potapov PV, Parker D, Stehman SV, Pickens AH, Parente LL, Ferreira LG, Song XP, Hernandez-Serna A, Kommareddy I.   +10 more
europepmc   +1 more source