Results 131 to 140 of about 2,788,771 (256)

The global human impact on biodiversity. [PDF]

Nature
Keck F, Peller T, Alther R, Barouillet C, Blackman R, Capo E, Chonova T, Couton M, Fehlinger L, Kirschner D, Knüsel M, Muneret L, Oester R, Tapolczai K, Zhang H, Altermatt F.   +15 more
europepmc   +1 more source

Determination of the human impact on the drop in NO₂ air pollution due to total COVID-19 lockdown using Human-Influenced Air Pollution Decrease Index (HIAPDI). [PDF]

Environ Pollut, 2022
Kovács KD.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Complex Variation in Afrotropical Mammal Communities With Human Impact. [PDF]

Ecol Evol
Tuyisingize D, Kulik L, Assou D, Zausa D, Kamga S, Mundi O, Heinicke S, Kone I, Mucyo SJP, Sop T, Boesch C, Stephens C, Agbor A, Angedakin S, Bailey E, Bessone M, Coupland C, Head J, Deschner T, Dieguez P, Egbe VE, Granjon AC, Hicks TC, Jones S, Kalan AK, Langergraber KE, Lapuente J, Lee KC, Lynn LK, Maldonado N, McCarthy MS, Meier A, Ormsby LJ, Piel AK, Sciaky L, Sommer V, Stewart FA, Wessling EG, Widness J, Wittig RM, Strohbach P, Arandjelovic M, van der Hoek Y, Kühl HS.   +43 more
europepmc   +1 more source

The past and future human impact on mammalian diversity. [PDF]

Sci Adv, 2020
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D.   +4 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Rapid development of an online tracker to communicate the human impact of abruptly halting PEPFAR support. [PDF]

J Int AIDS Soc
Nichols BE, Geng EH, Moakley E, Phillips AN, Imai-Eaton JW, Stover J, Mudimu E, Grimsrud A.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

8,000 years of wild and domestic animal body size data reveal long-term synchrony and recent divergence due to intensified human impact. [PDF]

Proc Natl Acad Sci U S A
Mureau C, d'Oliveira L, Peyron O, Blaise E, Renaud A, Balcarcel A, Jeanjean M, Bonhomme V, Bouby L, Ros J, Evin A.   +10 more
europepmc   +1 more source