Results 41 to 50 of about 2,769,323 (258)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Implementation Strategies Applied in Communities Matching Process (ISAC Match): Expanded Guidance and Case Study

Implementation Science
Background Implementation strategies are methods or techniques to improve the adoption, implementation, sustainment, and scale-up of evidence-based interventions.
Laura E. Balis, Taren Massey-Swindle, Shelly Palmer, Emily Shaw, Shelby Jones-Dozier, Michelle Grocke-Dewey   +5 more
doaj   +1 more source

Human-triggered earthquakes and their impacts on human security [PDF]

Nature Precedings, 2010
AbstractA comprehensive understanding of earthquake risks in urbanized regions requires an accurate assessment of both urban vulnerabilities and earthquake hazards. Socioeconomic risks associated with human-triggered earthquakes are often misconstrued and receive little scientific, legal, and public attention.
Christian Klose, Christian Klose
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Collecting Accurate and Robust Equity (CARE) data: an analysis of a pilot quality improvement initiative in ambulatory settings

BMJ Open Quality
Background Social determinants of health (SDoH) influence disease incidence, access to care, experiences, and outcomes. Recognising their importance, researchers and governments have emphasised the need to collect SDoH data in healthcare settings ...
Lawrence Mbuagbaw, Alison Fox-Robichaud, Fatima Sheikh, Lisa Schwartz, Jennifer Walker, Marlena Dang Nguyen, Kamal Babrah, Nili Begum, Nagham Azzam Iqbal, Rochelle Reid   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The psychological significance of female traditional initiation rites among the Bakopa community of South Africa: a qualitative approach to the understanding of koma ya basadi

Frontiers in Sociology
IntroductionFemale traditional initiation rites are deeply entrenched in the cultural fabric of many societies, representing profound rites of passage marking the transition from girlhood to womanhood.
Mmakotsedi Magampa, Thelmah Maluleke, Rudzani Marry Mhlari, Anastasia Julia Ngobe, Lehlogonolo Makola, Abongile Pindo, Alinah Segobye, Tholene Sodi   +7 more
doaj   +1 more source

The Impact of Past Human Activities on the Current State of Vegetation in Historical Settlements of a Wine-Growing Cultural Landscape (Svätý Jur, Slovakia)

Land, 2023
The aim of our study is to reconstruct the human influence on the current vegetation in selected parts of the cadastral territory of Svätý Jur. Svätý Jur is a town with more than 700 years of winemaking tradition, located on the oak-hornbeam-forested ...
Natália Hurajtová, Veronika Piscová, Petra Gašparovičová, Michal Ševčík   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Historical hypotheses of chimpanzee tool use behaviour in relation to natural and human-induced changes in an East African rain forest

Revue de Primatologie, 2014
Chimpanzees and humans have co-existed in Africa for millennia. The forests inhabited by chimpanzees have experienced numerous changes in recent time, most notably during the last 12,000 years, as the current interglacial age started.
Thibaud Gruber
doaj   +1 more source