Results 101 to 110 of about 2,774,595 (256)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Can the Wolf (Canis lupus) Thrive in Highly Anthropised Lowlands? First Habitat Suitability Analysis of the Po Plain, Italy

Animals
Coexisting with large carnivores in human-dominated European landscapes is a highly relevant and current challenge. Over the last two centuries, the wolf (Canis lupus) population in Europe has experienced a significant decline, primarily due to direct ...
Luca Fardone, Martina Forlani, Luca Canova, Matteo De Luca, Alberto Meriggi   +4 more
doaj   +1 more source

Microbial diversity and proxy species for human impact in Italian karst caves. [PDF]

Sci Rep, 2023
Biagioli F, Coleine C, Piano E, Nicolosi G, Poli A, Prigione V, Zanellati A, Varese C, Isaia M, Selbmann L.   +9 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human impacts [PDF]

Nature Climate Change, 2015
openaire   +2 more sources

Diversity, dynamics and biogeography of Chilean benthic nearshore ecosystems: an overview and guidelines for conservation Diversidad, dinámica y biogeografía del ecosistema costero bentónico de Chile: revisión y bases para conservación marina

Revista Chilena de Historia Natural, 2000
Despite Chile has been one of the pioneering countries in studies of human impact on marine communities, and despite the enormous economic and social significance that the marine environment has for the country, the development of marine conservation ...
MIRIAM FERNANDEZ, EDUARDO JARAMILLO, PABLO A MARQUET, CARLOS A MORENO, SERGIO A NAVARRETE, F. PATRICIO OJEDA, CLAUDIO R VALDOVINOS, JULIO A VASQUEZ   +7 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Early human impact on lake cyanobacteria revealed by a Holocene record of sedimentary ancient DNA. [PDF]

Commun Biol, 2023
Nwosu EC, Brauer A, Monchamp ME, Pinkerneil S, Bartholomäus A, Theuerkauf M, Schmidt JP, Stoof-Leichsenring KR, Wietelmann T, Kaiser J, Wagner D, Liebner S.   +11 more
europepmc   +1 more source