Results 41 to 50 of about 2,246,753 (218)

Requirements for automated micro-vehicles from the German public: a survey study

European Transport Research Review
This study investigates public requirements for and acceptance of semi-sized automated micro-vehicles (AMVs) in urban traffic in Germany, addressing safety and functional expectations from both incidentally co-present persons and potential delivery ...
Eva-Maria Schomakers, Vivian Lotz, Martina Ziefle   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Decoding Emotions From Brainwaves: The Impact of Wavelets and Overlap on EEG-Based Emotion Classification

Advances in Human-Computer Interaction
This study aimed to optimize emotion classification using electroencephalography (EEG) signals by evaluating the impact of window size, overlap, classification models, and wavelet transform selection.
A. Jarillo-Silva, J. A. Cruz-Tolentino, V. A. Gómez-Pérez, O. A. Domínguez-Ramírez, R. Hernández-Martínez   +4 more
doaj   +1 more source

Exploring a GPT-based large language model for variable autonomy in a VR-based human-robot teaming simulation

Frontiers in Robotics and AI
In a rapidly evolving digital landscape autonomous tools and robots are becoming commonplace. Recognizing the significance of this development, this paper explores the integration of Large Language Models (LLMs) like Generative pre-trained transformer ...
Younes Lakhnati, Max Pascher, Max Pascher, Jens Gerken   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Effects of Age and Gender on Adolescent Mental Health Stigma. An International Study in the Iberian Peninsula

Clínica y Salud. Investigación Empírica en Psicología
Background: Mental health stigma is a phenomenon present in adolescents. Age or gender are important variables to provide further intervention on stigma in this population.
Clara González-Sanguino, Leonor Pereira da Costa, Ana Carvalho, Bárbara de Sousa, Ana Beato   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Worlds apart? Investigating acceptance and usage demands of carbon-based cosmetics and clothing across European countries

Energy, Sustainability and Society
Background Global warming and the increasing risk of natural disasters force us all to act. As the reduction of carbon dioxide (CO2) emissions has been proven effective but insufficient on its own, Carbon Capture and Utilization (CCU) technologies ...
Wiktoria Wilkowska, Imke Tabea Haverkämper, Martina Ziefle   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source