Results 1 to 10 of about 93,317 (199)

Infant and adult human intestinal enteroids are morphologically and functionally distinct. [PDF]

mBio, 2023
UNLABELLED: Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants ...
Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng X-L, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Stossi F, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani S.   +15 more
europepmc   +11 more sources

2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids. [PDF]

J Virol
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment
Patil K, Ayyar BV, Hayes NM, Neill FH, Bode L, Estes MK, Atmar RL, Ramani S.   +7 more
europepmc   +11 more sources

Insights into human norovirus cultivation in human intestinal enteroids. [PDF]

mSphere
Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century.
Ettayebi K, Kaur G, Patil K, Dave J, Ayyar BV, Tenge VR, Neill FH, Zeng X-L, Speer AL, Di Rienzi SC, Britton RA, Blutt SE, Crawford SE, Ramani S, Atmar RL, Estes MK.   +15 more
europepmc   +9 more sources

Use of Human Intestinal Enteroids to Evaluate Persistence of Infectious Human Norovirus in Seawater. [PDF]

Emerg Infect Dis, 2022
Little data on the persistence of human norovirus infectivity are available to predict its transmissibility. Using human intestinal enteroids, we demonstrate that 2 human norovirus strains can remain infectious for several weeks in seawater.
Desdouits M, Polo D, Le Mennec C, Strubbia S, Zeng XL, Ettayebi K, Atmar RL, Estes MK, Le Guyader FS.   +8 more
europepmc   +9 more sources

25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids. [PDF]

J Virol
Norovirus is the leading cause of acute gastroenteritis worldwide. Since the development of human intestinal enteroid (HIE) cell culture systems, significant advancements have been made in exploring and evaluating therapeutic strategies to combat human ...
Costantini V, Mboko WP, Wall H, Huynh K, Montmayeur AM, Park GW, Xu R, Vinjé J, Chhabra P.   +8 more
europepmc   +6 more sources

Evaluation of Heat Inactivation of Human Norovirus in Freshwater Clams Using Human Intestinal Enteroids. [PDF]

Viruses, 2022
Foodborne disease attributed to consumption of shellfish contaminated with human norovirus (HuNoV) is one of many global health concerns. Our study aimed to determine conditions of heat-inactivation of HuNoV in freshwater clams (Corbicula japonica) using
Hayashi T, Yamaoka Y, Ito A, Kamaishi T, Sugiyama R, Estes MK, Muramatsu M, Murakami K.   +7 more
europepmc   +10 more sources

Human Intestinal Enteroids to Evaluate Human Norovirus GII.4 Inactivation by Aged-Green Tea. [PDF]

Front Microbiol, 2020
Human noroviruses are the leading cause of epidemic and sporadic acute gastroenteritis worldwide and the most common cause of foodborne illness in the United States.
Randazzo W, Costantini V, Morantz EK, Vinjé J.   +3 more
europepmc   +9 more sources

Human Norovirus Efficiently Replicates in Differentiated 3D-Human Intestinal Enteroids. [PDF]

J Virol, 2022
The human norovirus (HNoV) clinical and socio-economic impact calls for immediate action in the development of anti-infectives. Physiologically relevant in vitro models are hence needed to study HNoV biology, tropism, and mechanisms of viral-associated ...
Mirabelli C, Santos-Ferreira N, Gillilland MG, Cieza RJ, Colacino JA, Sexton JZ, Neyts J, Taube S, Rocha-Pereira J, Wobus CE.   +9 more
europepmc   +10 more sources

Effect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli. [PDF]

Acta Biomater, 2021
Human intestinal enteroids (HIE) models have contributed significantly to our understanding of diarrheal diseases and other intestinal infections, but their routine culture conditions fail to mimic the mechanical environment of the native intestinal wall.
Swaminathan G, Kamyabi N, Carter HE, Rajan A, Karandikar U, Criss ZK, Shroyer NF, Robertson MJ, Coarfa C, Huang C, Shannon TE, Tadros M, Estes MK, Maresso AW, Grande-Allen KJ.   +14 more
europepmc   +7 more sources

Differential Response to the Course of Cryptosporidium parvum Infection and Its Impact on Epithelial Integrity in Differentiated versus Undifferentiated Human Intestinal Enteroids. [PDF]

Infect Immun, 2022
Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients and causes waterborne outbreaks. Pathogenic mechanisms underlying diarrhea and intestinal dysfunction are poorly understood.
Lamisere H, Bhalchandra S, Kane AV, Zeng XL, Mo D, Adams W, Estes MK, Ward HD.   +7 more
europepmc   +4 more sources