Results 101 to 110 of about 93,317 (199)

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology [PDF]

Journal of Virology, 2015
ABSTRACT Human gastrointestinal tract research is limited by the paucity of in vitro intestinal cell models that recapitulate the cellular diversity and complex functions of human physiology and disease pathology.
K. Saxena, S. Blutt, K. Ettayebi, Xi-Lei Zeng, J. Broughman, S. Crawford, Umesh C. Karandikar, Narayan P. Sastri, M. Conner, A. Opekun, D. Graham, W. Qureshi, Vadim Sherman, Jennifer Foulke-Abel, Julie G. In, O. Kovbasnjuk, N. Zachos, M. Donowitz, M. Estes   +18 more
semanticscholar   +3 more sources

CVID Enteropathy Associated With Chronic Norovirus Infection: Background, Clinical Features, and Therapeutic Aspects

Reviews in Medical Virology, Volume 35, Issue 6, November 2025.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency, characterised by impaired antibody production, immune dysregulation, and a broad spectrum of clinical manifestations. Gastrointestinal involvement is frequent, affecting up to 20% of patients and significantly contributing to morbidity and ...
Györgyi Műzes, Ferenc Sipos
wiley   +1 more source

Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment

Scientific Reports
Lack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap in the management of these patients.
Vishwesh Bharadiya, Yan Rong, Zixin Zhang, Ruxian Lin, Anthony Lawrence Guerrerio, C. Ming Tse, Mark Donowitz, Varsha Singh   +7 more
doaj   +1 more source

Long-term culture of intestinal cell progenitors: an overview of their development, application, and associated technologies [PDF]

, 2016
Purpose of Review Long-term culture of adult progenitor cells in 3D is a recently emerging technology that inhabits the space between 2D cell lines and organ slice culture.
Hollins, Andrew John, Parry, Lee
core   +1 more source

Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. [PDF]

, 2020
Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Choi, Julie, Ear, Jason, Ghassemian, Majid, Ghosh, Pradipta, Kufareva, Irina, Rajapakse, Navin, Saklecha, Anokhi   +6 more
core  

The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair [PDF]

, 2015
In this study we characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids quantitative RT-PCR showed a time- and dose-dependent upregulation of lpa2 in ...
Balazs, Louisa, Balogh, Andrea, Banerje, Souvik, Bavaria, Mitul, Gangwar, Ruchika, Lee, Sue Chin, Miller, Duane D., Moon, ChangSuk, Naren, Anjaparavanda P., Norman, Derek D., Pelus, Louis, Rao, Radakrishna, Ray, Ramesh, Shimizu, Yoshibumi, Shukla, Pradeep, Tigyi, Gabor   +15 more
core   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

Hypoxia Affects Stem Cell Fate in Patient-Derived Ileum Enteroids in a HIF-1α-Dependent Manner. [PDF]

Cells
The intestinal epithelium maintains tissue homeostasis through a dynamic balance of stem cell proliferation and differentiation. This process is spatially regulated along the crypt–villus axis, with intestinal stem cells in the crypt regions ...
Uckeley ZM, Kee C, Ramirez C, Karaluz V, Sharma AK, Polanco J, Ortiz Martinez FD, Mederos CI, Jacobs SO, Groose IJ, Ramsden JM, Herrmann C, Stanifer ML, Boulant S.   +13 more
europepmc   +2 more sources

Alistipes senegalensis is Critically Involved in Gut Barrier Repair Mediated by Panax Ginseng Neutral Polysaccharides in Aged Mice

Advanced Science, Volume 12, Issue 36, September 25, 2025.
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang, Hui Wang, Yingna Li, Jing Lu, Xiaolei Tang, Dan Yang, Manying Wang, Daqing Zhao, Fangbing Liu, Shuai Zhang, Liwei Sun   +10 more
wiley   +1 more source

Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges [PDF]

Viruses, 2019
Noroviruses, in the genus Norovirus, are a significant cause of viral gastroenteritis in humans and animals. For almost 50 years, the lack of a cultivation system for human noroviruses (HuNoVs) was a major barrier to understanding virus biology and the development of effective antiviral strategies.
Mary K. Estes, Khalil Ettayebi, Victoria R. Tenge, Kosuke Murakami, Umesh Karandikar, Shih-Ching Lin, B. Vijayalakshmi Ayyar, Nicolas W. Cortes-Penfield, Kei Haga, Frederick H. Neill, Antone R. Opekun, James R. Broughman, Xi-Lei Zeng, Sarah E. Blutt, Sue E. Crawford, Sasirekha Ramani, David Y. Graham, Robert L. Atmar   +17 more
openaire   +3 more sources