Results 111 to 120 of about 93,317 (199)

IFN-γ-Induced intestinal epithelial cell-type-specific programmed cell death: PANoptosis and its modulation in Crohn’s disease

Frontiers in Immunology
BackgroundCrohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) and is considered a Th1-mediated disease, supported by the over-expression of interferon-gamma (IFN-γ) in the intestinal lamina propria.
Chansu Lee, Chansu Lee, Ji Eun Kim, Yeo-Eun Cha, Yeo-Eun Cha, Ji Hwan Moon, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong, Sung Noh Hong   +10 more
doaj   +1 more source

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Disease Models & Mechanisms, 2020
Inflammatory bowel diseases (IBDs) cause significant morbidity and mortality. Aberrant NF-κB signalling is strongly associated with these conditions, and several established drugs influence the NF-κB signalling network to exert their effect.
Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos, Alexander Kel, Werner Muller, D. Mark Pritchard, Chris Probert, Michael D. Burkitt, The SysmedIBD Consortium   +19 more
doaj   +1 more source

FFAR4 drives stem cell fate toward lipid- and iron-storing enterocytes protecting human enteroids from ferroptosis. [PDF]

Stem Cell Res Ther
Background Intestinal stem cell (ISC) fate is directed by microenvironmental cues, partly regulated through surface receptors, many of which remain incompletely characterized.
Farhadipour M, Leng H, Thijs T, Dubois A, Deleus E, Van der Schueren B, Lannoo M, Ceulemans LJ, Ferrante M, Depoortere I.   +9 more
europepmc   +2 more sources

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress [PDF]

, 2017
Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium.
Kraft, Crystal, Lynch, John P., Pattison, Amanda M., Rappaport, Jeff A., Snook, Adam E., Waldman, Scott A.   +5 more
core   +2 more sources

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, Volume 12, Issue 23, June 20, 2025.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Apical-out bovine intestinal organoids as an infection model for Cryptosporidium parvum

Current Research in Parasitology and Vector-Borne Diseases
Cryptosporidium parvum is a major pathogen responsible for neonatal calf diarrhoea, but research has been hampered due to the lack of in vitro models that can complete the life cycle.
Mathilde Svensen Varegg, Lucy J. Robertson, Lise Benette Nilsen Hovd, Maria Stokstad, Alejandro Jiménez-Meléndez   +4 more
doaj   +1 more source

Host-microbe interaction in the gastrointestinal tract [PDF]

, 2017
The gastrointestinal tract is a highly complex organ in which multiple dynamic physiological processes are tightly coordinated while interacting with a dense and extremely diverse microbial population.
Abrams G.D., Benveniste J., Benveniste J., Carabotti M., Guenet J.L., Iwai H., Kulkarni D.H., Marshall B., PastuBa A., Shroff K.E., Sprinz H.   +10 more
core   +1 more source

A Dynamic Double‐Flow Gut‐On‐Chip Model for Predictive Absorption Studies In Vitro

Advanced Materials Technologies, Volume 10, Issue 9, May 6, 2025.
This study presents a novel millifluidic gut‐on‐chip model using the MIVO® device to replicate human intestinal conditions. Dynamic co‐culture of CaCo‐2 and HT‐29 cells accelerates differentiation, modulates mucus thickness, and enhances barrier function.
Maria Elisabetta Federica Palamà, Maurizio Aiello, Gergő Borka, Jacopo Furci, Ilaria Parodi, Giuseppe Firpo, Silvia Scaglione   +6 more
wiley   +1 more source

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB ActivationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background and Aims: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill ...
Jerry Wong, Ricard Garcia-Carbonell, Matija Zelic, Samuel B. Ho, Brigid S. Boland, Shih-Jing Yao, Shalin A. Desai, Soumita Das, Núria Planell, Philip A. Harris, Joan Font-Burgada, Koji Taniguchi, John Bertin, Azucena Salas, Manolis Pasparakis, Pete J. Gough, Michelle Kelliher, Michael Karin, Monica Guma   +18 more
doaj   +1 more source

Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions

Journal of Extracellular Vesicles, Volume 14, Issue 5, May 2025.
ABSTRACT This study explores the virulence mechanisms of Vibrio cholerae, with a particular emphasis on HapA, a zinc metalloprotease delivered via outer membrane vesicles (OMVs). The findings reveal that OMV‐associated HapA disrupts the integrity of tight and adherens junctions in intestinal epithelial cell models more effectively than its purified ...
Palwasha Baryalai, David Irenaeus, Eric Toh, Madeleine Ramstedt, Bernt Eric Uhlin, Aftab Nadeem, Sun Nyunt Wai   +6 more
wiley   +1 more source