Results 121 to 130 of about 93,317 (199)
Advanced Science, Volume 12, Issue 9, March 6, 2025.In this work, a human primary cell‐based immunocompetent model is established to investigate early responses to STm infection. Intestinal fibroblasts and monocyte‐derived macrophages are embedded in decellularized small intestinal submucosa (SIS) from domestic pigs, followed by the development of an enteroid monolayer.
Spyridon Damigos +10 more
wiley +1 more source
In Vitro Culture of Human Norovirus in the Last 20 Years
BiomedicinesHuman noroviruses (HuNoVs) are the main pathogens that cause acute gastroenteritis and lead to huge economic losses annually. Due to the lack of suitable culture systems, the pathogenesis of HuNoVs and the development of vaccines and drugs have ...
Chao Cheng +5 more
doaj +1 more source
Sixth European seminar in virology on virus\u2013host interaction at single cell and organism level [PDF]
, 2018 The 6th European Seminar in Virology (EuSeV) was held in Bertinoro, Italy, 22\u201324 June 2018, and brought together international scientists and young researchers working in the field of Virology.
Pal\uf9, Giorgio +4 more
core +1 more source
Apical‐out Tubuloids for Accurate Kidney Toxicity Studies
Aggregate, Volume 6, Issue 3, March 2025.Apical‐out tubuloids are developed to study apical drug transport and drug‐induced nephrotoxicity. These tubuloids exhibit primary cilia and relevant structural proteins, indicating apical‐out polarity and enhanced functionality. Functional assays, including bovine serum albumin uptake, confirm their physiological relevance for studying apical ...
Yugyeong Lee +10 more
wiley +1 more source
VirusesHuman norovirus (HuNoV) is a leading global cause of viral gastroenteritis, contributing to numerous outbreaks and illnesses annually. However, conventional cell culture systems cannot support the cultivation of infectious HuNoV, making its detection and
Sahaana Chandran, Kristen E. Gibson
doaj +1 more source
Establishment of a Novel Caco‐2‐Based Cell Culture System for Human Sapovirus Propagation
Genes to Cells, Volume 30, Issue 2, March 2025.We identified that both Caco‐2 cells and in‐house Caco‐2/Cas9 cells are susceptible to human sapovirus (HuSaV) infection. By performing two rounds of single‐cell cloning from Caco‐2/Cas9 cells, we successfully established a highly susceptible cell line, designated as Caco‐2MC.
Yuya Fukuda +7 more
wiley +1 more source
Chemistry – A European Journal, Volume 31, Issue 10, February 17, 2025.We synthesized BODIPY dyes with benzyl ester and carboxylic acid groups, showing charge transfer, polarity‐dependent triplet state formation, and pH‐dependent emission. Fluorescence lifetime microscopy revealed distinct lifetime gradients in colon cancer cells and pig enteroids.
Aimee Sheehan +5 more
wiley +1 more source
Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization [PDF]
, 2019 Author summary The intestinal epithelium is a crucial biological interface, interacting with both commensal and pathogenic microorganisms. It’s lined with heavily glycosylated proteins and glycolipids which can act as both attachment sites and energy ...
Baines, J. +12 more
core +1 more source
Exosome-mediated human norovirus infection.
PLoS ONE, 2020 Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV ...
Kyle V Todd, Ralph A Tripp
doaj +1 more source
Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies. [PDF]
, 2015 Congenital diarrhoeal disorders (CDDs) represent an evolving web of rare chronic enteropathies, with a typical onset early in life. In many of these conditions, severe chronic diarrhoea represents the primary clinical manifestation, whereas in others ...
BERNI CANANI, ROBERTO +4 more
core +1 more source