Results 131 to 140 of about 93,317 (199)

Establishment and long-term maintenance of primary intestinal epithelial cells cultured from the rainbow trout,Oncorhynchus mykiss. [PDF]

, 2018
A novel method for the establishment and long-term maintenance ofex vivocultures from intestinal regions of the rainbow trout,Oncorhynchus mykiss(Walbaum), is reported. Adherence of cells was observed within hours, epithelial island formation recorded at
Beaulieu, Evans, Flouriot, Petrinec, Pärt, Wood   +5 more
core   +3 more sources

Microfluidic device facilitates in vitro modeling of human neonatal necrotizing enterocolitis–on-a-chip

JCI Insight, 2023
Necrotizing enterocolitis (NEC) is a deadly gastrointestinal disease of premature infants that is associated with an exaggerated inflammatory response, dysbiosis of the gut microbiome, decreased epithelial cell proliferation, and gut barrier disruption ...
Wyatt E. Lanik, Cliff J. Luke, Lila S. Nolan, Qingqing Gong, Lauren C. Frazer, Jamie M. Rimer, Sarah E. Gale, Raymond Luc, Shay S. Bidani, Carrie A. Sibbald, Angela N. Lewis, Belgacem Mihi, Pranjal Agrawal, Martin Goree, Marlie Maestas, Elise Hu, David G. Peters, Misty Good   +17 more
doaj   +1 more source

Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection [PDF]

, 2018
Several viruses induce intestinal epithelial cell death during enteric infection. However, it is unclear whether proapoptotic capacity promotes or inhibits replication in this tissue.
Aravamudhan, Pavithra, Brown, Judy J., Dermody, Terence S., Ikizler, Mine, Jabri, Bana, Khomandiak, Solomiia, McAllister, Nicole, Pruijssers, Andrea J., Short, Sarah P., Stencel-Baerenwald, Jennifer, Taylor, Gwen, Urbanek, Kelly, Williams, Christopher S.   +12 more
core  

Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

, 2022
Shih‐Ching Lin, Kei Haga, Xi‐Lei Zeng, Mary K. Estes   +3 more
openalex   +2 more sources

Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]

, 2018
Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita, Parija, Subas Chandra, Rattan, Satish, Suklabaidya, Sujit   +3 more
core   +2 more sources

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]

, 2020
Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni, Horvath, Steve, Jones, D Leanne, Lewis, Sophia K, Martin, Martin G, Nachun, Daniel   +5 more
core  

Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids

Gut microbes, 2018
Disruption of intestinal barrier homeostasis is an important pathogenic factor in conditions such as irritable bowel syndrome (IBS). Lactobacillus rhamnosus GG (LGG) improves IBS symptoms through unclear mechanisms.
Xu Han, Allen A. Lee, Sha Huang, Jun Gao, J. Spence, C. Owyang   +5 more
semanticscholar   +1 more source

Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Frontiers in Immunology
IntroductionThe intestinal epithelium of human infants is developmentally immature compared to that of adults. Exactly how this immaturity affects key epithelial functions and their interactions with nearby immune cells remains an understudied area of ...
Zohreh Sharafian, Zohreh Sharafian, Paula T. Littlejohn, Paula T. Littlejohn, Paula T. Littlejohn, Christina Michalski, Christina Michalski, James A. Sousa, James A. Sousa, Janelle Cheung, Mariana Hill, Mariana Hill, Hannah Piper, Kevan Jacobson, Kevan Jacobson, Pascal M. Lavoie, Pascal M. Lavoie, Joannie M. Allaire, Bruce A. Vallance, Bruce A. Vallance   +19 more
doaj   +1 more source

Neonatal enteroids absorb extracellular vesicles from human milk‐fed infant digestive fluid

Journal of Extracellular Vesicles
Human milk contains extracellular vesicles (HMEVs). Pre‐clinical models suggest that HMEVs may enhance intestinal function and limit inflammation; however, it is unknown if HMEVs or their cargo survive neonatal human digestion. This limits the ability to
Claire Yung, Yang Zhang, Madeline Kuhn, Randall J. Armstrong, Amy Olyaei, Molly Aloia, Brian Scottoline, Sarah F. Andres   +7 more
doaj   +1 more source

Differentiation and Protective Capacity of Virus-Specific CD8 [PDF]

, 2017
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown.
Bengsch, Bertram, Cosma, Gabriela L., Eisenlohr, Laurence C., Lau, Chi Wai, Manne, Sasikanth, Nice, Timothy J., Palko, Olesya, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Tomov, Vesselin T., Virgin, Herbert W., Wherry, E. John   +12 more
core   +1 more source