Intestinal Enteroid Monolayers Model the Human Intestinal Environment for Escherichia coli Infection [PDF]
Journal of Bacteriology, 2022 O157:H7 is difficult to study due to its high specificity for the human intestine and the lack of sufficiently complex human cell culture models. The recent development of human intestinal enteroids derived from intestinal crypt multipotent stem cells has allowed us to construct two-dimensional differentiated epithelial monolayers grown in transwells ...
Jason T. Small, Alison A. Weiss
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Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. [PDF]
Cell Mol Gastroenterol Hepatol, 2019 Chang-Graham AL +8 more
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Correction for Murakami et al., Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids. [PDF]
Proc Natl Acad Sci U S A, 2020 europepmc +3 more sources
Porcine small intestinal organoids as a model to explore ETEC–host interactions in the gut
Veterinary Research, 2021 Small intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much research has been done on murine and human enteroids, however only a handful studies evaluated the ...
Bjarne Vermeire +4 more
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TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s DiseaseSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Tumor necrosis factor alpha (TNFα) is considered a major tissue damage-promoting effector in Crohn’s disease (CD) pathogenesis. Patient-derived intestinal organoid (enteroid) recapitulates the disease-specific characteristics of ...
Chansu Lee +6 more
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Human Intestinal Enteroids as a Model System of Shigella Pathogenesis. [PDF]
Infect Immun, 2019 The enteric bacterium and intracellular human pathogen Shigella causes hundreds of millions of cases of the diarrheal disease shigellosis per year worldwide. Shigella is acquired by ingestion of contaminated food or water; upon reaching the colon, the bacteria invade colonic epithelial cells,
Koestler BJ +5 more
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iScience, 2023 Summary: Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche.
Mona Farhadipour +10 more
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Antioxidants, 2023 Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined.
Alena Golubkova +9 more
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Establishing Human Intestinal Enteroid/Organoid Lines from Preterm Infant and Adult Tissue
, 2020 Self-organizing mini-intestines cultured ex vivo from intestinal biopsy/resected samples, termed intestinal organoids or enteroids, present a unique opportunity for mechanistic investigation of health and disease of the intestinal epithelium. These patient-derived epithelial cultures are nontransformed, retain the genetic background of the patient ...
Christopher J. Stewart +2 more
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Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct
bioRxiv, 2023 Background & Aims Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants ...
Grace O. Adeniyi-Ipadeola +15 more
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