The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]
, 2020 The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita +9 more
core +3 more sources
Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]
, 2015 Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M +14 more
core +2 more sources
Interferon-lambda: A potent regulator of intestinal viral infections [PDF]
, 2017 Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core +8 more sources
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Comparison of Surgical and Cadaveric Intestine as a Source of Crypt Culture in Humans
Cell Transplantation, 2020 Human small intestinal crypts are the source of intestinal stem cells (ISCs) that are capable of undergoing self-renewal and differentiation to an epithelial layer.
Andrew Scott +12 more
doaj +1 more source
Journal of Lipid Research, 2017 Since its initial report in 2009, the intestinal enteroid culture system has been a powerful tool used to study stem cell biology and development in the gastrointestinal tract. However, a major question is whether enteroids retain intestinal function and
Javeed Jattan +7 more
doaj +1 more source
CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection
Nature Communications, 2023 Culture methods for studying human norovirus infection have been recently established. Here, Ayyar and colleagues use human intestinal enteroids to dissect viral entry mechanisms and show that CLIC-mediated endocytosis and wound repair pathways are ...
B. Vijayalakshmi Ayyar +10 more
doaj +1 more source
Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]
, 2016 : Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY +3 more
core +1 more source
Replication and transcriptionomic analysis of human noroviruses in human intestinal enteroids. [PDF]
Am J Transl Res, 2019 Lin L +7 more
europepmc +2 more sources